Wolfram syndrome, caused by WFS1 or CISD2 gene mutations, disrupts ER Ca2+ regulation in neurons. Here, the authors show how these mutations impair ER-mitochondria interactions, compromise Ca2+ transfer and mitochondrial function, and lead to bioenergetic deficits and oxidative stress.
- Mailis Liiv
- Annika Vaarmann
- Allen Kaasik