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Showing 1–5 of 5 results

Advanced filters: Author: Mario-Ernesto Cruz-Munoz Clear advanced filters

Do NK cells always need a license to kill?

The ability of natural killer cells to eliminate abnormal cells has been shown to be enhanced by triggering of certain inhibitory receptors during their maturation. New data show that sometimes the opposite can happen.

Mario-Ernesto Cruz-Munoz
André Veillette
News & Views01 Apr 2010
Nature Immunology

Volume: 11, P: 279-280
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

Romain Roncagalli
James E R Taylor
André Veillette
Research28 Aug 2005
Nature Immunology

Volume: 6, P: 1002-1010
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

The biological function of the SLAM family receptor CRACC is not known. Using a CRACC-deficient mouse, Veillette and colleagues show that CRACC can activate or inhibit natural killer cells, depending on the availability of the adaptor EAT-2.

Mario-Ernesto Cruz-Munoz
Zhongjun Dong
André Veillette
Research18 Jan 2009
Nature Immunology

Volume: 10, P: 297-305
Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

SAP family adaptors, including SAP, EAT-2 and ERT, individually influence natural killer cell function. Veillette and colleagues show that natural killer cells lacking all three adaptors fail to eliminate unwanted hematopoietic cells.

Zhongjun Dong
Mario-Ernesto Cruz-Munoz
André Veillette
Research02 Aug 2009
Nature Immunology

Volume: 10, P: 973-980
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin

The identification of homotypic SLAMF7 interactions responsible for haematopoietic tumour cell phagocytosis by macrophages when the inhibitory receptor/ligand interaction of SIRPα/CD47 is blocked therapeutically.

Jun Chen
Ming-Chao Zhong
André Veillette
Research19 Apr 2017
Nature

Volume: 544, P: 493-497