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Showing 1–3 of 3 results
Advanced filters: Author: Marion Massop Clear advanced filters

  • Joop Jansen and colleagues report the identification of somatic mutations altering the histone methyltransferase EZH2 in myelodysplastic syndromes. They find EZH2 deletions, missense and frameshift mutations in about 23% of myelodysplastic syndrome samples.

    • Gorica Nikoloski
    • Saskia M C Langemeijer
    • Joop H Jansen
    Research
    Nature Genetics
    Volume: 42, P: 665-667

  • Myelodysplastic syndromes are a broad group of haematopoietic malignancies that often progress to acute myeloid leukaemia. Here, the authors show that linear and branched evolution occurs within myelodysplastic syndrome and these patterns can be impacted by treatment.

    • Pedro da Silva-Coelho
    • Leonie I. Kroeze
    • Joop H. Jansen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Joop Jansen and colleagues show that myelodysplastic syndromes frequently harbor somatic mutations in TET2. Analysis of lineage markers suggests that TET2 mutations are early events contributing to malignant transformation.

    • Saskia M C Langemeijer
    • Roland P Kuiper
    • Joop H Jansen
    Research
    Nature Genetics
    Volume: 41, P: 838-842