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Showing 1–3 of 3 results
Advanced filters: Author: Marisa Nacke Clear advanced filters

  • The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to control this switch.

    • Marisa Nacke
    • Emma Sandilands
    • David M. Bryant
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • There are currently a lack of tools to detect heterogeneity in 3D cultures. Here the authors report Traject3d as a framework to identify heterogeneous states in 3D culture and to understand how these give rise to distinct phenotypes using label-free multi-day time-lapse imaging.

    • Eva C. Freckmann
    • Emma Sandilands
    • David M. Bryant
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • During de novo establishment of apical-basal polarity, a basolateral membrane must be converted into an apical delivery zone. Here, the authors use MDCK 3D cysts to uncover that the phospholipid PI(3,4)P2 is an apical membrane determinant.

    • Álvaro Román-Fernández
    • Julie Roignot
    • David M. Bryant
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17