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Showing 1–4 of 4 results
Advanced filters: Author: Marissa L. Calbert Clear advanced filters

  • Polθ helicase is crucial for DNA repair and a target for precision medicine for cancer therapy. Here, the authors reveal the mechanism of action of the small-molecule inhibitor AB25583, and show its high specificity and selective killing of BRCA1/2– cancer cells and synergy with olaparib.

    • Fumiaki Ito
    • Ziyuan Li
    • Richard T. Pomerantz
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Chandramouly et al. discover that human Polλ exhibits robust microhomology-mediated end-joining (MMEJ) activity like PolΦ. Polλ promotes MMEJ in mammalian cells independently of essential nonhomologous end-joining factors LIG4/XRCC4 and Polq, which indicates a distinct Polλ-dependent MMEJ mechanism.

    • Gurushankar Chandramouly
    • Joonas Jamsen
    • Richard T. Pomerantz
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 107-114