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Showing 1–7 of 7 results
Advanced filters: Author: Mark A Arbing Clear advanced filters

  • Cancer genomes are rife with genetic variants, and one key outcome of this variation is widespread gain-of-cysteine mutations. Here, the authors pair cysteine chemoproteomics with genomics to investigate the landscape of cysteine genetic variation.

    • Heta Desai
    • Katrina H. Andrews
    • Keriann M. Backus
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • A short segment of α-synuclein called NACore (residues 68–78) is responsible for the formation of amyloid aggregates responsible for cytotoxicity in Parkinson disease; here the nanocrystal structure of this invisible-to-optical-microscopy segment is determined using micro-electron diffraction, offering insight into its function and simultaneously demonstrating the first use of micro-electron diffraction to solve a previously unknown protein structure.

    • Jose A. Rodriguez
    • Magdalena I. Ivanova
    • David S. Eisenberg
    Research
    Nature
    Volume: 525, P: 486-490

  • A cell-free system for cannabinoid production uses only low-cost inputs with 12 enzymes and can operate either aerobically or anaerobically, in addition to reducing ATP requirements by use of an engineered system for malonate-CoA biosynthesis.

    • Meaghan A. Valliere
    • Tyler P. Korman
    • James U. Bowie
    Research
    Nature Chemical Biology
    Volume: 16, P: 1427-1433

  • A single-molecule forced unfolding of E. coli chloride transporter ClC-ec1 shows that the N- and C-terminal halves of the protein unfold independently, with exposed polar surfaces stabilized by membrane lipid head groups and water.

    • Duyoung Min
    • Robert E. Jefferson
    • James U. Bowie
    Research
    Nature Chemical Biology
    Volume: 14, P: 489-496

  • A cryo-EM structure of a membrane-embedded core complex of the ESX-3/type VII secretion system from Mycobacterium smegmatis is reported, providing insights into the mechanisms by which virulence factors are secreted by these bacteria.

    • Nikolaos Famelis
    • Angel Rivera-Calzada
    • Sebastian Geibel
    Research
    Nature
    Volume: 576, P: 321-325