APOBEC3 cytidine deaminases have been implicated in restriction of retroviruses and retrotransposons in mammalian cells. Now human APOBEC3A is shown to be upregulated by interferon and to catalyze the deamination of foreign double-stranded DNA transfected into primary cells or cell lines, with no detectable effect on genomic DNA.
- Mark D Stenglein
- Michael B Burns
- Reuben S Harris