Nature Search

A single generation of domestication heritably alters the expression of hundreds of genes

Little is known about the genetic underpinnings of the earliest stages of plant and animal domestication. Here, the authors show that steelhead trout respond to a single generation of domestication selection with large, heritable changes in expression of genes regulating immunity and metabolism.

Mark R. Christie
Melanie L. Marine
Michael S. Blouin
ResearchOpen Access17 Feb 2016
Nature Communications

Volume: 7, P: 1-6
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R Burton
David G Clayton
Matthew A Brown
Research21 Oct 2007
Nature Genetics

Volume: 39, P: 1329-1337
FOREARM VASCULAR RESISTANCE IN THE UPPER AND LOWER QUINTILES OF BLOOD PRESSURE IN ADOLESCENT BOYS: The Muscatine Study

Larry T Mahoney
William R Clarke
Ronald M Lauer
Research01 Feb 1982
Pediatric Research

Volume: 16, P: 163-165
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

A transancestral exome-wide association study for body-fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.

Anne E. Justice
Tugce Karaderi
Cecilia M. Lindgren
Research18 Feb 2019
Nature Genetics

Volume: 51, P: 452-469
Trace benzene capture by decoration of structural defects in metal–organic framework materials

Benzene is a genotoxic carcinogen with no safe level of exposure. Here, by creating and decorating a structural defect in a metal–organic framework to form MIL-125-Zn, a benzene uptake of 7.63 mmol g^–1 at 1.2 mbar is observed due to binding to Zn(II) sites.

Yu Han
Wenyuan Huang
Sihai Yang
ResearchOpen Access29 Oct 2024
Nature Materials

Volume: 23, P: 1531-1538
Spatial working memory in humans as revealed by PET

John Jonides
Edward E. Smith
Mark A. Mintun
Research17 Jun 1993
Nature

Volume: 363, P: 623-625
Prion protein is necessary for normal synaptic function

John Collinge
Miles A. Whittington
John G. R. Jefferys
Research28 Jul 1994
Nature

Volume: 370, P: 295-297
Images of aurorae on Jupiter from H⁺₃ emission at 4 μm

Sang J. Kim
Pierre Drossart
Mark Shure
Research10 Oct 1991
Nature

Volume: 353, P: 536-539
Probing the phagolysosomal environment of human macrophages with a Ca²⁺-responsive operon fusion in Yersinia pestis

Charles Pollack
Susan C. Straley
Mark S. Klempner
Research28 Aug 1986
Nature

Volume: 322, P: 834-836
Rare and low-frequency coding variants alter human adult height

Data from over 700,000 individuals reveal the identity of 83 sequence variants that affect human height, implicating new candidate genes and pathways as being involved in growth.

Eirini Marouli
Mariaelisa Graff
Guillaume Lettre
Research01 Feb 2017
Nature

Volume: 542, P: 186-190
Genome-wide atlas of gene expression in the adult mouse brain

The expression of each of the roughly 22,000 genes of the mouse genome has been mapped, at cellular resolution, across all major structures of the mouse brain, revealing that 80% of all genes appear to be expressed in the brain.

Ed S. Lein
Michael J. Hawrylycz
Allan R. Jones
Research06 Dec 2006
Nature

Volume: 445, P: 168-176
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Matthew H. Bailey
William U. Meyerson
Christian von Mering
Amendments and CorrectionsOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1
The 1993–94 Généthon human genetic linkage map

Gabor Gyapay
Jean Morissette
Jean Weissenbach
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 246-339
Effect of depth-dependent viscosity on the planform of mantle convection

Hans-Peter Bunge
Mark A. Richards
John R. Baumgardner
Research01 Feb 1996
Nature

Volume: 379, P: 436-438
Low magnetic flux noise observed in laser-deposited in situ films of YB₂Cu₃O_y and implications for high- T_c SQUIDs

M. J. Ferrari
Mark Johnson
T. Venkatesan
Research26 Oct 1989
Nature

Volume: 341, P: 723-725
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials

Andrew H. Sinclair
Jamie W. Foster
Jennifer A. Marshall Graves
Research29 Dec 1988
Nature

Volume: 336, P: 780-783
Genetic variants associated with longitudinal changes in brain structure across the lifespan

Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

Rachel M. Brouwer
Marieke Klein
Hilleke E. Hulshoff Pol
Research05 Apr 2022
Nature Neuroscience

Volume: 25, P: 421-432
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The regulation of resistance to IDH inhibitors in acute myeloid leukaemia is not completely understood. Here the authors reveal with integrative multi-omics analyses that stemness features are major drivers of primary resistance, while high-risk mutations drive acquired resistance.

Feng Wang
Kiyomi Morita
Koichi Takahashi
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-13
Crystal structure of the anti-fungal target N-myristoyl transferase

Simon A. Weston
Roger Camble
Richard A. Pauptit
Research01 Mar 1998
Nature Structural Biology

Volume: 5, P: 213-221
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.

Felix R Day
Katherine S Ruth
Anna Murray
Research28 Sept 2015
Nature Genetics

Volume: 47, P: 1294-1303
Submarine terraced deposits linked to periodic collapse of caldera-forming eruption columns

Submarine terraced deposits of some caldera-forming explosive eruptions result from periodic collapses of the eruption column and can be used to estimate their source eruption rate, according to an analysis of such terraces and analogue experiments.

Johan T. Gilchrist
A. Mark Jellinek
Sean Wanket
Research10 Apr 2023
Nature Geoscience

Volume: 16, P: 446-453
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index. Gene-based meta-analysis and functional studies implicate 13 genes, eight of which are novel, and neuronal pathways as factors in human obesity.

Valérie Turcot
Yingchang Lu
Ruth J. F. Loos
Research22 Dec 2017
Nature Genetics

Volume: 50, P: 26-41
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival

Analyses of clinical and genomic data from a cohort of 2,336 patients with pancreatic adenocarcinoma find that KRAS dosage gains are a hallmark of disease progression and are predictive of poor outcomes across different disease stages.

Anna M. Varghese
Maria A. Perry
Eileen M. O’Reilly
ResearchOpen Access03 Jan 2025
Nature Medicine

Volume: 31, P: 466-477
Gamma-rays and X-rays from SN1987A

Mark D. Leising
Research07 Apr 1988
Nature

Volume: 332, P: 516-518
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari
Constance H. Li
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Ruth Loos and colleagues report results of a large genome-wide association study for body mass index. They identify 18 new loci associated with this trait, some of which map near key hypothalamic regulators of energy balance.

Elizabeth K Speliotes
Cristen J Willer
Ruth J F Loos
Research10 Oct 2010
Nature Genetics

Volume: 42, P: 937-948
Author Correction: Pan-cancer analysis of whole genomes

Lauri A. Aaltonen
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E39
Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Biotechnology

Volume: 41, P: 577
Author Correction: The landscape of viral associations in human cancers

Marc Zapatka
Ivan Borozan
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1077
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Author Correction: Genomic basis for RNA alterations in cancer

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E37
Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling
Chen Hong
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Yiqun Zhang
Fengju Chen
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Inferring structural variant cancer cell fraction

Marek Cmero
Ke Yuan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Author Correction: Patterns of somatic structural variation in human cancer genomes

Yilong Li
Nicola D. Roberts
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E38
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1076
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Cancer Pathways' target not validated by clinical results

Mark Ratner
Research01 Mar 1999
Nature Biotechnology

Volume: 17, P: 220
PDGF induction of tyrosine phosphorylation of GTPase activating protein

Christopher J. Molloy
Donald P. Bottaro
Stuart A. Aaronson
Research07 Dec 1989
Nature

Volume: 342, P: 711-714
The Laschamp geomagnetic ‘event’

MARK NÖEL
D. H. TARLING
Research01 Feb 1975
Nature

Volume: 253, P: 705-707
Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Here the authors report an exploratory analysis of a clinical trial that tested different influenza virus vaccination platforms. The results show that multiple seasons of recombinant or cell-based influenza vaccinations may be needed to redirect antibody responses away from immune memory to egg-adapted epitopes and refocus on epitopes on the circulating viruses.

Feng Liu
F. Liaini Gross
Min Z. Levine
ResearchOpen Access04 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

Yuan Yuan
Young Seok Ju
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1078
Association between pathologic response and survival after neoadjuvant therapy in lung cancer

Analysis of the phase 3 CheckMate 816 trial shows that the depth of pathologic response as assessed by percent residual viable tumor is correlated with event-free survival following neoadjuvant immunotherapy plus chemotherapy, supporting pathologic response as a biomarker of survival.

Julie Stein Deutsch
Ashley Cimino-Mathews
Janis M. Taube
ResearchOpen Access30 Oct 2023
Nature Medicine

Volume: 30, P: 218-228

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