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Showing 1–6 of 6 results
Advanced filters: Author: Mark D. Okusa Clear advanced filters

  • In this Review, Mark Okusa and colleagues discuss the role of neural circuits in the control of renal inflammation as well as the therapeutic potential of targeting these circuits in the settings of acute kidney injury, kidney fibrosis and hypertension.

    • Mark D. Okusa
    • Diane L. Rosin
    • Kevin J. Tracey
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 669-680

  • Neutrophils, lymphocytes, macrophages and dendritic cells mediate the inflammatory response which damages the kidney during ischemia–reperfusion. This Review provides a concise summary of the complex hypoxia-induced interactions between these components of the immune system. The role of the renal-circulation regulator adenosine and its cellular receptors is then discussed, and the potential for adenosine agonists to ameliorate ischemia–reperfusion injury examined.

    • Li Li
    • Mark D Okusa
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 2, P: 432-444

  • The difficulties that are currently inherent in early diagnosis of acute kidney injury could be overcome by the introduction of biomarkers into routine clinical practice. Here, Bruce Molitoris and colleagues provide an update of the status of development of biomarkers for this indication. Transcriptomics, proteomics, and gene array and imaging technologies are just some of the methods being harnessed to drive the discovery process. Subsequent validation in high quality clinical trials will be essential.

    • Bruce A Molitoris
    • Vyacheslav Y Melnikov
    • Jonathan Himmelfarb
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 154-165

  • Acute stress elicits physiological and behavioral responses that enhance survival. This study in mice shows that stress reduces tissue injury in a model of renal ischemia-reperfusion injury by activating an anti-inflammatory response via the sympathetic system and the spleen. C1 neurons located in the brainstem mediate this protective effect of stress.

    • Chikara Abe
    • Tsuyoshi Inoue
    • Patrice G Guyenet
    Research
    Nature Neuroscience
    Volume: 20, P: 700-707

  • The prevalence of cognitive dysfunction among people with chronic kidney disease (CKD) is disproportionately high compared with that in the general population. This Review examines current evidence on key drivers of cognitive impairment in people with CKD, and highlights gaps in knowledge and potential therapeutic targets.

    • Giovambattista Capasso
    • Casper F. M. Franssen
    • Robert J. Unwin
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 536-552

  • Perivascular cells have beneficial roles that maintain kidney homeostasis but can also contribute to kidney pathology. Here, the authors focus mainly on pericytes and fibroblasts to examine these roles, including the contribution of perivascular cells to the myofibroblast pool in kidney fibrosis, and their crosstalk with tubular, immune and endothelial cells.

    • Shinji Tanaka
    • Didier Portilla
    • Mark D. Okusa
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 721-732