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Showing 1–3 of 3 results
Advanced filters: Author: Mark Eiseman Clear advanced filters

  • Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.

    • Jun Sun
    • Dong Yeon Shin
    • Matthew B. Greenblatt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Neurofibromatosis type I (NF1) is characterized by prominent skeletal abnormalities mediated in part by aberrant ERK pathway activation due to NF1 loss-of-function. Here, the authors report the MEKK2 is a key mediator of this aberrant ERK activation and that MEKK2 inhibitors, including ponatinib, ameliorate skeletal defects in a mouse model of NF1.

    • Seoyeon Bok
    • Dong Yeon Shin
    • Matthew B. Greenblatt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10