Nepon-Sixt, Bryant, and Alexandrow show that Myc increases the chromatin accessibility through Myc-Box II, activating Cdc45-MCM-GINS helicases at Myc-targeted sites. This study highlights a non-transcriptional role for Myc in over-activating DNA replication, providing insight into Myc-driven tumorigenesis.
- Brook S. Nepon-Sixt
- Victoria L. Bryant
- Mark G. Alexandrow