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Showing 1–9 of 9 results
Advanced filters: Author: Mark Lautens Clear advanced filters

  • While the oxidative addition of Pd to carbon–halide bonds is often regarded as being essentially irreversible, this is sometimes not the case. This Perspective looks at the conditions leading to reductive elimination of Pd from carbon–halide bonds, and the synthetic opportunities that this offers are discussed.

    • David J. Jones
    • Mark Lautens
    • Gerard P. McGlacken
    Reviews
    Nature Catalysis
    Volume: 2, P: 843-851

  • C–H functionalization of organic compounds is an ideal yet challenging approach to organic synthesis. This Perspective covers the most recent developments concerning the palladium-catalysed norbornene-mediated C–H functionalization of arenes, including applications of these methodologies in natural products synthesis. Challenges as well as opportunities for future studies are also presented.

    • Juntao Ye
    • Mark Lautens
    Reviews
    Nature Chemistry
    Volume: 7, P: 863-870

  • Chemist who developed ways to synthesize and depict bioactive products.

    • Mark Lautens
    Comments & Opinion
    Nature
    Volume: 606, P: 859

  • Although carbometallation reactions have been thoroughly investigated, understanding the factors responsible for the reverse reaction (β-carbon elimination) is an emerging area of research. Now, a series of substrates has been investigated to study the key factors that promote β-carbon elimination under palladium catalysis.

    • Austin D. Marchese
    • Bijan Mirabi
    • Mark Lautens
    Research
    Nature Chemistry
    Volume: 14, P: 398-406

  • Plant-parasitic nematodes have the potential to destroy crops globally, and limited options for managing nematode infestation are available. Here, the authors report the 1,3,4-oxadiazole thioether scaffold called Cyprocide that selectively kills nematodes including diverse species of plant-parasitic nematodes.

    • Jessica Knox
    • Andrew R. Burns
    • Peter J. Roy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A metabolically bioactivated selective imidazothiazole nematicide shows comparable effectiveness at controlling plant root infection by Meloidogyne incognita to commercial nematicides, which are traditionally nonselective and toxic.

    • Andrew R. Burns
    • Rachel J. Baker
    • Peter J. Roy
    Research
    Nature
    Volume: 618, P: 102-109

  • Harrington et al report their discovery of Nemacol, which is a small molecule inhibitor of the vesicular acetylcholine transporter (VAChT). VAChT loads synaptic vesicles with acetylcholine and is a key point of vulnerability in animals. Harrington et al show that Nemacol has nematode selectivity and potential utility against nematode parasites.

    • Sean Harrington
    • Jacob Pyche
    • Peter J. Roy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Existing methods for C–H activation depend on pre-installed directing groups, the removal of which poses a practical limitation on the use of these reactions in synthesis. Now, a remote-selective C−H alkylation reaction of arenes using an in situ generated spiropalladacycle has been shown to furnish benzofurans and indoles without the need for a directing group.

    • Juntao Ye
    • Zhihao Shi
    • Mark Lautens
    Research
    Nature Chemistry
    Volume: 9, P: 361-368