Nature Search

A turbulent year at the agency

If there's a positive message to take away from the FDA's seemingly endless troubles in 2005, it may be that smaller companies are increasingly registering on the agency's radar.

Mark Ratner
Special Features01 Feb 2006
Nature Biotechnology

Volume: 24, P: 145-151
Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages

Here the authors describe a stabilization technology that engineers crosslinks between tyrosine sidechains into a natively folded vaccine immunogen and show that immunogenicity is improved in small animal models by locking the most potently neutralizing epitopes.

Sonal V. Gidwani
Devarshi Brahmbhatt
Mark A. Yondola
ResearchOpen Access14 Mar 2024
Nature Communications

Volume: 15, P: 1-14
Hybrid insulin cocrystals for controlled release delivery

Mark L. Brader
Muppalla Sukumar
Sharon R. Myers
Research22 Jul 2002
Nature Biotechnology

Volume: 20, P: 800-804
Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat

Donna M. Brown
Abraham P. Provoost
Howard J. Jacob
Research01 Jan 1996
Nature Genetics

Volume: 12, P: 44-51
Crystalline-State Configurations of Alkylene Sulfide Polymers

William J Welsh
James E Mark
Evaristo Riande
Research01 Jul 1980
Polymer Journal

Volume: 12, P: 467-472
Seawater cycled throughout Earth’s mantle in partially serpentinized lithosphere

The dominant source for water in Earth’s mantle is unclear. Geochemical analyses of rock samples from mid-ocean ridges and ocean islands globally suggest the water is largely derived from seawater-altered crust introduced during subduction.

M. A. Kendrick
C. Hémond
M. R. Perfit
Research27 Feb 2017
Nature Geoscience

Volume: 10, P: 222-228
An accelerated pathway for targeted cancer therapies

Mark McClellan
Joshua Benner
David Kessler
Comments & Opinion01 Feb 2011
Nature Reviews Drug Discovery

Volume: 10, P: 79-80
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Michael Talkowski and colleagues analyze balanced chromosomal abnormalities in 273 individuals by whole-genome sequencing. Their findings suggest that sequence-level resolution improves prediction of clinical outcomes for balanced rearrangements and provides insight into pathogenic mechanisms such as altered gene regulation due to changes in chromosome topology.

Claire Redin
Harrison Brand
Michael E Talkowski
Research14 Nov 2016
Nature Genetics

Volume: 49, P: 36-45
Centromere mechanical maturation during mammalian cell mitosis

During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood. Here, the authors report that mechanical stiffnness of the centromere matures during mitotic progression and is amplified specifically at metaphase.

Lauren A. Harasymiw
Damien Tank
Melissa K. Gardner
ResearchOpen Access15 Apr 2019
Nature Communications

Volume: 10, P: 1-21
Development of The Immune System in Very Low Birth Weight (Less than 1500 g) Premature Infants: Concentrations of Plasma Immunoglobulins and Patterns of Infections

Mark Ballow
K Lynn Cates
Charlene Desbonnet
Research01 Sept 1986
Pediatric Research

Volume: 20, P: 899-904
Estradiol pauses microtubule growth without increased incidence of catastrophe events

Overgrowth of cellular microtubules (MTs) is associated with a range of disease processes. Cellular and biophysical reconstitution experiments reveal that estradiol transforms dynamic, growing MTs into paused, non-growing MTs.

Allison N. Ogren
Noah J. Zimmerman
Melissa K. Gardner
ResearchOpen Access18 Jun 2025
Communications Biology

Volume: 8, P: 1-14
A FISH study of trisomies 7 and 8 in prostate cancer

H F L Mark
S Das
D Feldman
Research Highlights01 Jan 1999
Genetics in Medicine

Volume: 1, P: 69
The potential for artificial intelligence to transform healthcare: perspectives from international health leaders

Christina Silcox
Eyal Zimlichmann
David W. Bates
ReviewsOpen Access09 Apr 2024
npj Digital Medicine

Volume: 7, P: 1-3
Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma

Michael H. Elliott
Nicole E. Ashpole
W. Daniel Stamer
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Implementation of a fully remote randomized clinical trial with cardiac monitoring

Mayfield et al. describe the implementation and feasibility of an exclusively remote randomized clinical trial of hydroxychloroquine and azithromycin for the treatment of COVID-19. The trial included monitoring of cardiovascular safety which was successfully done using digital technologies.

Jacob J. Mayfield
Neal A. Chatterjee
Arun R. Sridhar
ResearchOpen Access20 Dec 2021
Communications Medicine

Volume: 1, P: 1-10

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