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Showing 1–6 of 6 results
Advanced filters: Author: Mark P. Dodding Clear advanced filters

  • The kinesin-1 motor protein accesses open active and closed autoinhibited states. These states are regulated by a flexible elbow within a complex coiled-coil architecture. Now, a conformational switch has been developed by engineering the elbow to create a closed state that can be controllably opened with a de novo designed peptide to increase kinesin transport inside cells.

    • Jessica A. Cross
    • William M. Dawson
    • Derek N. Woolfson
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 916-923

  • Using focused ion beam milling and cryoelectron tomography, Tsuji et al. found actin filaments, with both cofilin-bound and canonical morphologies, within the lumen of human platelet microtubules and reconstituted these structures in vitro.

    • Chisato Tsuji
    • Marston Bradshaw
    • Mark P. Dodding
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Mitochondrial biogenesis and maintenance relies on protein import from the cytosol. Here, authors show that import failure impacts organelle structure and dynamics. They also identify a rescue mechanism involving intercellular mitochondrial transfer.

    • Hope I. Needs
    • Emily Glover
    • Ian Collinson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The de novo design of a pair of complementary peptides, one basic for cell penetration and target binding and one acidic that can be fused to proteins of interest, provides an approach for delivery into mammalian cells and subcellular targeting.

    • Guto G. Rhys
    • Jessica A. Cross
    • Derek N. Woolfson
    Research
    Nature Chemical Biology
    Volume: 18, P: 999-1004

  • Control of the activity of the microtubule motor cytoplasmic dynein 1 is essential for its function in intracellular transport. A recent paper by McKenney et al. published in Science shows that activation of processive dynein motility requires the formation of cargo adaptor-dynein-dynactin complexes.

    • Mark P Dodding
    Research Highlights
    Cell Research
    Volume: 24, P: 1385-1386