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Showing 1–10 of 10 results
Advanced filters: Author: Mark R Looney Clear advanced filters

  • PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.

    • Gilles Rademaker
    • Grace A. Hernandez
    • Rushika M. Perera
    Research
    Nature
    Volume: 643, P: 1381-1390

  • Fast, two-photon intravital imaging of a mechanically stabilized and physiologically intact preparation of the mouse lung is reported. It is used to monitor immune cells in the lung under normal and injured conditions.

    • Mark R Looney
    • Emily E Thornton
    • Matthew F Krummel
    Research
    Nature Methods
    Volume: 8, P: 91-96

  • Patients with mild COVID-19 show a pattern of interferon-stimulated gene (ISG) expression across all major cell types, but in patients with severe disease, antibodies block the production of these ISG-expressing cells.

    • Alexis J. Combes
    • Tristan Courau
    • Matthew F. Krummel
    Research
    Nature
    Volume: 591, P: 124-130

  • Experiments in two mouse models of thromboinflammatory disease show how neutrophils stick to red blood cells and platelets—leading to reduced blood flow and damage to the microcirculation. Polarized expression of αMβ2 integrins on neutrophils helps set the process in motion (pages 384–391).

    • Mark R Looney
    • Michael A Matthay
    News & Views
    Nature Medicine
    Volume: 15, P: 364-366

  • Interaction between platelets and neutrophils promotes neutrophil activation. Here the authors show that neutrophils initiate the cross-talk with platelets by shuttling arachidonic acid via extracellular vesicles, which platelets convert to thromboxane A2that then elicits neutrophil activation.

    • Jan Rossaint
    • Katharina Kühne
    • Alexander Zarbock
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.

    • Mark B. Headley
    • Adriaan Bins
    • Matthew F. Krummel
    Research
    Nature
    Volume: 531, P: 513-517

  • Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch signalling pathway to repair the epithelium after bleomycin- or influenza-mediated injury; inappropriate Notch signalling may be a major contributor to failed regeneration within the lungs of patients with chronic lung disease.

    • Andrew E. Vaughan
    • Alexis N. Brumwell
    • Harold A. Chapman
    Research
    Nature
    Volume: 517, P: 621-625