Nature Search

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to the HH pathway inhibitor vismodegib is cell-type specific.

Jennifer Karin Ocasio
Benjamin Babcock
Timothy R. Gershon
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-17
Chromosome 5 allele loss in human colorectal carcinomas

E. Solomon
R. Voss
S. H. Rider
Research13 Aug 1987
Nature

Volume: 328, P: 616-619
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition the microenvironment and promote anti-tumor immunity.

Giulia Agliardi
Anna Rita Liuzzi
Burkhard Becher
ResearchOpen Access19 Jan 2021
Nature Communications

Volume: 12, P: 1-11
Implementation of the Deutsch–Jozsa algorithm on an ion-trap quantum computer

Stephan Gulde
Mark Riebe
Rainer Blatt
Research02 Jan 2003
Nature

Volume: 421, P: 48-50
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Haoyu Zhang
Thomas U. Ahearn
Montserrat García-Closas
Research18 May 2020
Nature Genetics

Volume: 52, P: 572-581
High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

Among many populations of blood cells, high dimensional analysis using mass cytometry reveals classical monocyte frequency as strong predictors of response to PD-1 blockade therapy of melanoma.

Carsten Krieg
Malgorzata Nowicka
Burkhard Becher
Research08 Jan 2018
Nature Medicine

Volume: 24, P: 144-153
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Philip Washbourne
Peter M. Thompson
Michael C. Wilson
Research19 Dec 2001
Nature Neuroscience

Volume: 5, P: 19-26
Functional interdependence of BRD4 and DOT1L in MLL leukemia

The histone methyltransferase DOT1L and the chromatin reader BRD4 together facilitate transcription of genes critical to the molecular pathogenesis of MLL leukemia.

Omer Gilan
Enid Y N Lam
Mark A Dawson
Research13 Jun 2016
Nature Structural & Molecular Biology

Volume: 23, P: 673-681
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Philip C. Wong
Hui Zheng
Sangram S. Sisodia
Research15 May 1997
Nature

Volume: 387, P: 288-292
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

Marcela V. Karpuj
Mark W. Becher
Lawrence Steinman
Research01 Feb 2002
Nature Medicine

Volume: 8, P: 143-149
Solute Focusing Techniques for Bioseparations

Lisa L. Evans
Mark A. Burns
Reviews01 Jan 1995
Bio/Technology

Volume: 13, P: 46-52
Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

Streptomyces bacteria make volatile compounds such as geosmin and 2-methylisoborneol that attract springtails to bacterial colonies. The soil arthropods feed on the bacteria and help to disseminate spores via faecal pellets and through adherence to their surface.

Paul G. Becher
Vasiliki Verschut
Klas Flärdh
Research06 Apr 2020
Nature Microbiology

Volume: 5, P: 821-829
Observation of roton mode population in a dipolar quantum gas

The roton energy spectrum, originally introduced by Landau, explains the thermodynamic behaviour of strongly interacting liquid helium at low temperature. Now, a similar spectrum has been observed in weakly interacting dipolar quantum gas.

L. Chomaz
R. M. W. van Bijnen
F. Ferlaino
Research05 Mar 2018
Nature Physics

Volume: 14, P: 442-446
Brown adipose tissue is associated with cardiometabolic health

Retrospective analysis of ¹⁸F-FDG PET/CT scans from over 50,000 patients reveals correlations between presence of brown adipose tissue and lower odds of having cardiometabolic conditions, such as type 2 diabetes, cardiovascular disease and hypertension.

Tobias Becher
Srikanth Palanisamy
Paul Cohen
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 58-65
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Jingjing Liu
Wendy J. C. Prager - van der Smissen
Antoinette Hollestelle
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
Automated and virus variant-programmable surrogate test qualitatively compares to the gold standard SARS-CoV-2 neutralization assay

Danielle W. Ali
Maggie L. Bartlett
Darci R. Smith
ResearchOpen Access30 Dec 2024
npj Viruses

Volume: 2, P: 1-8
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

Mark J Alkema
Heinz Jacobs
Anton Berns
Research21 Aug 1997
Oncogene

Volume: 15, P: 899-910
Atom-at-a-time laser resonance ionization spectroscopy of nobelium

Resonance ionization spectroscopy of nobelium (atomic number 102) reveals its ground-state transition and an upper limit for its ionization potential, paving the way to characterizing even heavier elements via optical spectroscopy.

Mustapha Laatiaoui
Werner Lauth
Alexander Yakushev
Research28 Sept 2016
Nature

Volume: 538, P: 495-498
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587

Search

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

Chromosome 5 allele loss in human colorectal carcinomas

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Implementation of the Deutsch–Jozsa algorithm on an ion-trap quantum computer

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

Solute Focusing Techniques for Bioseparations

Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

Observation of roton mode population in a dipolar quantum gas

Brown adipose tissue is associated with cardiometabolic health

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Automated and virus variant-programmable surrogate test qualitatively compares to the gold standard SARS-CoV-2 neutralization assay

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

Atom-at-a-time laser resonance ionization spectroscopy of nobelium

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

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