Nature Search

Sonochemical synthesis of amorphous iron

Kenneth S. Suslick
Seok-Burm Choe
Mark W. Grinstaff
Research03 Oct 1991
Nature

Volume: 353, P: 414-416
Mega macromolecules as single molecule lubricants for hard and soft surfaces

Synthetic globular polymers of several million molecular weight are expected to exhibit unique properties but are difficult to synthesize. Here the authors synthesize such dendritic polymers that show unique lubrication properties and act as molecular ball bearings due to their 3D compact structure, size, solubility, hydration and low intrinsic viscosities.

Parambath Anilkumar
Taylor B. Lawson
Jayachandran N. Kizhakkedathu
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-9
Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

In NAFLD, high levels of fatty acids in the liver impair lysosomal acidification. Here, the authors report the synthesis of novel biodegradable acid-activated acidifying nanoparticles that re-acidify lysosomes, restore autophagy, and reverse fasting hyperglycemia and hepatic steatosis in fat mice.

Jialiu Zeng
Rebeca Acin-Perez
Mark W. Grinstaff
ResearchOpen Access04 May 2023
Nature Communications

Volume: 14, P: 1-17
A progesterone biosensor derived from microbial screening

Bacteria represent an unexploited reservoir of biosensing proteins. Here the authors use genomic screens and functional assays to isolate a progesterone sensing allosteric transcription factor and use a FRET-based method to develop an optical progesterone sensor.

Chloé Grazon
R C. Baer
James E. Galagan
ResearchOpen Access09 Mar 2020
Nature Communications

Volume: 11, P: 1-10
Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages

Difficulty with purification, structural heterogenicity, and limited water solubility of β-glucans has significantly limited their therapeutic applications. Here, the authors report the synthesis of (1→6)-β-glucose-branched poly-amido-saccharides as glycan-mimetics and demonstrate macrophage stimulation and polarization.

Ruiqing Xiao
Jialiu Zeng
Mark W. Grinstaff
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-13
Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission

Measurements of solid stresses in breast tumours by means of intravital microscopy of tumour-embedded hydrogel beads shows that the transmission of solid stresses depends on length scale and on the tumour microenvironment.

Sue Zhang
Gabrielle Grifno
Hadi T. Nia
Research28 Aug 2023
Nature Biomedical Engineering

Volume: 7, P: 1473-1492
Sustainable polycarbonate adhesives for dry and aqueous conditions with thermoresponsive properties

Adhesives are ubiquitous in commodity products, however it it essential that their synthesis and degradation be sustainable without compromising their performance. Here, the authors report a library of adhesives based on environmentally benign building blocks that perform in both dry and wet environments.

Anjeza Beharaj
Ethan Z. McCaslin
Mark W. Grinstaff
ResearchOpen Access02 Dec 2019
Nature Communications

Volume: 10, P: 1-7
A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

Comprehensive multi-tissue single-cell atlas of human knee osteoarthritis reveals distinct chondrocytes, inflammatory macrophages, osteogenic stem cells, and synovial fibroblasts offering critical insights into mechanisms and therapies.

Rajnikant Dilip Raut
Amit Kumar Chakraborty
Manish V. Bais
ResearchOpen Access02 Aug 2025
Communications Biology

Volume: 8, P: 1-18
Polymer–drug conjugate therapeutics: advances, insights and prospects

The conjugation of therapeutic agents to polymer carriers, such as polyethylene glycol (PEG), can control drug delivery, enhance solubilization, increase efficacy and improve pharmacokinetics. Here, Grinstaff, Colson and Ekladious discuss recent advances in the preclinical and clinical development of different classes of polymer–drug conjugates and highlight current challenges and future directions.

Iriny Ekladious
Yolonda L. Colson
Mark W. Grinstaff
Reviews12 Dec 2018
Nature Reviews Drug Discovery

Volume: 18, P: 273-294
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury

The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regeneration.

Shanmugam Muruganandan
Rachel Pierce
Andreia M. Ionescu
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-15
IRGM1 links mitochondrial quality control to autoimmunity

Fessler and colleagues report that loss of the IFN-γ-induced GTPase IRGM1 results in autoinflammatory disease. Deficient IRGM1 activity led to defective lysosomal maturation and impaired mitophagy, prompting the release of cytosolic mtDNA and thereby activating the cGAS–STING pathway.

Prashant Rai
Kyathanahalli S. Janardhan
Michael B. Fessler
Research28 Jan 2021
Nature Immunology

Volume: 22, P: 312-321
Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency

Complete 5-methylcytidine substitution enhances the efficacy of self-amplifying RNA.

Joshua E. McGee
Jack R. Kirsch
Mark W. Grinstaff
Research08 Jul 2024
Nature Biotechnology

Volume: 43, P: 720-726
Advancing pressure-sensitive adhesives for internal wound closure

Pressure-sensitive adhesives are familiar household items spanning applications in everyday repair, office supplies and topical wound care. Through innovations in material and polymer science, pressure-sensitive adhesives will advance from current commodity to new specialty materials with resulting new clinical uses and improved patient care.

Danielle M. Fitzgerald
Yolonda L. Colson
Mark W. Grinstaff
Comments & Opinion18 Nov 2022
Nature Reviews Materials

Volume: 8, P: 3-5
Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy

Joint lubrication is important for minimizing friction between articulating joint surfaces and for preventing cartilage wear that can otherwise exacerbate osteoarthritis. This Review examines the advantages and disadvantages of various strategies for restoring normal joint lubrication.

Christian D. DeMoya
Anisha Joenathan
Mark W. Grinstaff
Reviews10 Jun 2024
Nature Reviews Rheumatology

Volume: 20, P: 432-451
Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Annina E. A. Saukko
Mikael J. Turunen
Juha Töyräs
ResearchOpen Access08 May 2019
Scientific Reports

Volume: 9, P: 1-9
Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

Petri Paakkari
Satu I. Inkinen
Juuso T. J. Honkanen
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Prophylactic administration of miR-451 inhibitor decreases osteoarthritis severity in rats

Kayla M. Scott
D. Joshua Cohen
Zvi Schwartz
ResearchOpen Access27 Sept 2022
Scientific Reports

Volume: 12, P: 1-10
Electrode material–ionic liquid coupling for electrochemical energy storage

The development of efficient, high-energy and high-power electrochemical energy-storage devices requires a systems-level holistic approach, rather than focusing on the electrode or electrolyte separately. In this Review, we discuss the interfacial reactions and ion transport in ionic-liquid-based Li-ion batteries and supercapacitors, and summarize their impact on device performance.

Xuehang Wang
Maryam Salari
Yury Gogotsi
Reviews23 Jul 2020
Nature Reviews Materials

Volume: 5, P: 787-808
A Markov chain model of particle deposition in the lung

Adam H. Sonnenberg
Jacob Herrmann
Béla Suki
ResearchOpen Access11 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

Chunwan Lu
Dafeng Yang
Kebin Liu
Research30 Mar 2022
Oncogene

Volume: 41, P: 2651-2662
Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

Daniel S. Reynolds
Kristie M. Tevis
Mark W. Grinstaff
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
Two-Step Delivery: Exploiting the Partition Coefficient Concept to Increase Intratumoral Paclitaxel Concentrations In vivo Using Responsive Nanoparticles

Aaron H. Colby
Rong Liu
Mark W. Grinstaff
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Petri Paakkari
Satu I. Inkinen
Juuso T. J. Honkanen
ResearchOpen Access10 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Sensing Native Protein Solution Structures Using a Solid-state Nanopore: Unraveling the States of VEGF

Nitinun Varongchayakul
Diana Huttner
Amit Meller
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-9

Search

Sonochemical synthesis of amorphous iron

Mega macromolecules as single molecule lubricants for hard and soft surfaces

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

A progesterone biosensor derived from microbial screening

Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages

Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission

Sustainable polycarbonate adhesives for dry and aqueous conditions with thermoresponsive properties

A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

Polymer–drug conjugate therapeutics: advances, insights and prospects

A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury

IRGM1 links mitochondrial quality control to autoimmunity

Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency

Advancing pressure-sensitive adhesives for internal wound closure

Advances in viscosupplementation and tribosupplementation for early-stage osteoarthritis therapy

Simultaneous Quantitation of Cationic and Non-ionic Contrast Agents in Articular Cartilage Using Synchrotron MicroCT Imaging

Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

Prophylactic administration of miR-451 inhibitor decreases osteoarthritis severity in rats

Electrode material–ionic liquid coupling for electrochemical energy storage

A Markov chain model of particle deposition in the lung

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

Two-Step Delivery: Exploiting the Partition Coefficient Concept to Increase Intratumoral Paclitaxel Concentrations In vivo Using Responsive Nanoparticles

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Sensing Native Protein Solution Structures Using a Solid-state Nanopore: Unraveling the States of VEGF

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