This study demonstrates that the cytosolic helicases RIG-I and MDA5 act to negatively regulate the expansion of the encephalitogenic TH1 and TH17 T cells via a mechanism that induces type I interferon production specifically in dendritic cells. Activating this pathway leads to decreased pathology in response to CNS autoimmunity.
- Angela Dann
- Hendrik Poeck
- Marco Prinz
