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Nature Reviews Cancer (1)

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

The tumour suppressor FBW7 is the substrate recognition component of the SCF-type ubiquitin ligase that degrades several proto-oncogenes, including MYC and cyclin E. How do the numerous cancer-associated mutations inFBW7and its substrates contribute to tumorigenesis?

Markus Welcker
Bruce E. Clurman
Reviews01 Feb 2008
Nature Reviews Cancer

Volume: 8, P: 83-93

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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