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Advanced filters: Author: Marlène Marcellin Clear advanced filters

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

There are many patients who do not respond to immune checkpoint inhibitor (ICI) immunotherapy. Here, the authors show a significant negative correlation between sphingosine kinase-1 (SK1) expression and survival for ICI-treated melanoma patients, and further show that targeting SK1 improves response to ICI in mouse cancer models.

Caroline Imbert
Anne Montfort
Céline Colacios
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Themis2 lowers the threshold for B cell activation during positive selection

Cornall and colleagues show that Themis2 interacts with the phospholipase PLC-γ2 and lowers the threshold for B cell activation by low but not high avidity antigens.

Daian Cheng
Mukta Deobagkar-Lele
Richard J Cornall
Research19 Dec 2016
Nature Immunology

Volume: 18, P: 205-213
sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial

David M. Smadja
Clément R. Massonnaud
Benjamin Leveau
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-16
Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Alexandre Denadai-Souza
Chrystelle Bonnart
Céline Deraison
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-9

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