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Showing 1–4 of 4 results

Advanced filters: Author: Marlesa I. Godoy Clear advanced filters

Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms

The molecular mechanisms that regulate postnatal termination of neurogenesis remain poorly described. Here authors report Prdm16 deletion leads to the retention of radial glia in adulthood and prolonged postnatal neuroblast production.

Jiwen Li
Marlesa I. Godoy
Ye Zhang
ResearchOpen Access19 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hypoxic and inflammatory conditions.

Jiwen Li
Lin Pan
Ye Zhang
ResearchOpen Access25 Jun 2021
Nature Communications

Volume: 12, P: 1-20
Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

A phase 1/2a study shows that human neural progenitor cells modified to release the growth factor GDNF are safely transplanted into the spinal cord of patients with ALS, with cell survival and GDNF production for over 3 years.

Robert H. Baloh
J. Patrick Johnson
Clive N. Svendsen
ResearchOpen Access05 Sept 2022
Nature Medicine

Volume: 28, P: 1813-1822
Young bone marrow transplantation preserves learning and memory in old mice

Melanie Das et al. demonstrate that transplantation of young bone marrow preserves the cognitive function of old recipient mice. This study suggests that microglial rejuvenation via peripheral manipulation of the hematopoietic system may be sufficient to delay a cognitive decline during aging.

Melanie M. Das
Marlesa Godoy
Helen S. Goodridge
ResearchOpen Access20 Feb 2019
Communications Biology

Volume: 2, P: 1-10