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Showing 1–4 of 4 results
Advanced filters: Author: Marlous L Grijsen Clear advanced filters

  • Initiating antiretroviral therapy (ART) during primary HIV-1 infection (PHI) may influence long-term viral persistence, yet its enduring effects remain unclear. Here, Pasternak and colleagues demonstrate that temporary ART started early in infection reduces HIV-1 proviral diversity and monocyte activation, and sustains lower levels of viral persistence markers, suggesting a lasting suppressive impact on the HIV-1 reservoir.

    • Alexander O. Pasternak
    • Pien M. van Paassen
    • Ben Berkhout
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Leprosy is a chronic infectious disease that causes considerable morbidity in marginalized communities. In this Primer, Grijsen et al. summarize the epidemiology and mechanisms of leprosy, discuss its diagnosis, management and patient quality of life, and highlight areas for future research.

    • Marlous L. Grijsen
    • Thuan H. Nguyen
    • Annemieke Geluk
    Reviews
    Nature Reviews Disease Primers
    Volume: 10, P: 1-18

  • The rapid mutation rate of HIV-1 enables its escape from neutralizing antibodies (NAbs) in infected individuals. Bunnik et al. now show that the immune pressure exerted by NAbs has, over the course of the HIV epidemic, altered the HIV-1 envelope glycoprotein such that HIV-1 variants isolated from recently infected individuals are more resistant to NAbs, compared with viral variants isolated from individuals infected at the start of the epidemic. Their results suggest the need to carefully select the envelope gene used in today's vaccine efforts.

    • Evelien M Bunnik
    • Zelda Euler
    • Hanneke Schuitemaker
    Research
    Nature Medicine
    Volume: 16, P: 995-997