Coffer and colleagues report that the transcription factor FOXO3 regulates the induction of autophagy. In response to PI(3)K–Akt signalling, FOXO3 directly induces expression of glutamine synthase, which upregulates glutamine levels and triggers autophagy.
- Kristan E. van der Vos
- Pernilla Eliasson
- Paul J. Coffer
