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Showing 1–10 of 10 results
Advanced filters: Author: Marta Costa Figueiredo Clear advanced filters

  • Zebrafish patient-derived xenograft models (zAvatar) can be used to study cancer biology as well as to predict patient clinical outcomes and response to therapies. Here, in a cohort of 55 patients with colorectal cancer, the authors report that the zAvatar-test can predict response to chemotherapy and clinical outcome with 91% accuracy.

    • Bruna Costa
    • Marta F. Estrada
    • Rita Fior
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Here the authors screen different lipid nanoparticle (LNP) formulations for intramuscular delivery of plasmid DNA and uptake by antigen-presenting cells. The lead LNP exhibits immunogenicity and protection in small animal models that is comparable to approved SARS-CoV-2 mRNA vaccine formulations.

    • Lays Cordeiro Guimaraes
    • Pedro Augusto Carvalho Costa
    • Pedro Pires Goulart Guimaraes
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Trypanosoma brucei parasites invade different organs, such as the central nervous system, adipose tissue, and skin in mammalian host. Here, Trindade et al. perform mathematical modelling to show that adipose tissue forms (ATFs) grow slower than the bloodstream forms and experimentally characterize the heterogeneous ATF populations and provide evidence that slow-growing forms are refractory to drug treatment.

    • Sandra Trindade
    • Mariana De Niz
    • Luisa M. Figueiredo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

    • Ana S. Guerreiro Stucklin
    • Scott Ryall
    • Cynthia Hawkins
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • The electrochemical synthesis of high-value chemicals is still far from industrial application, mostly due to the lack of stable and efficient catalysts. Now evidence reveals that gaining a fundamental understanding of an electrochemical reaction can lead to faster development of optimal catalytic materials.

    • Marta C. Figueiredo
    News & Views
    Nature Catalysis
    Volume: 3, P: 4-5

  • The simultaneous electroreduction of carbon dioxide and nitrate is a promising and environmentally benign route to urea production, but achieving high selectivity for urea electrosynthesis via this route remains challenging. Here, CuOxZnOy electrodes are shown to enable the efficient and selective production of urea under mild conditions, with the efficiency found to strongly depend on the metal ratio within the catalyst composition.

    • Dimitra Anastasiadou
    • Bianca Ligt
    • Marta Costa Figueiredo
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-8

  • Co-electrolysis of nitrogen oxides and carbon oxides has been studied for over two decades but remains largely inefficient with numerous persisting knowledge voids. Here, the authors report a thermodynamic basis for modelling urea production via co-electrolysis using several exchange-correlation functionals, highlighting the importance of gas-phase error assessment in computational electrocatalysis.

    • Ricardo Urrego-Ortiz
    • Santiago Builes
    • Federico Calle-Vallejo
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10

  • Borges et al. study the dynamics of SARS-CoV-2 in Portugal during 2020. The authors use phylodynamic modelling to infer patterns of SARS-CoV-2 introduction into Portugal and its subsequent spread, providing a comprehensive genomic epidemiology study of the early SARS-CoV-2 epidemic in Portugal.

    • Vítor Borges
    • Joana Isidro
    • João Paulo Gomes
    ResearchOpen Access
    Communications Medicine
    Volume: 2, P: 1-11