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Showing 1–7 of 7 results
Advanced filters: Author: Marta Joana Costa Jordão Clear advanced filters

  • The transcription factor Nr4a1 can negatively regulate norepinephrine production in the context of neuroinflammation and thereby prevent the ensuing neuroinflammatory cascade in a mouse model of experimental autoimmune encephalomyelitis.

    • Marta Joana Costa Jordão
    • Marco Prinz
    News & Views
    Nature Immunology
    Volume: 16, P: 1211-1213

  • Microglia progenitors seed the central nervous system from the yolk sac, but little is known about the origin of non-parenchymal macrophages. Prinz and colleagues demonstrate that these macrophages in the central nervous system are related to but distinct from microglia and are largely of embryonic origin.

    • Tobias Goldmann
    • Peter Wieghofer
    • Marco Prinz
    Research
    Nature Immunology
    Volume: 17, P: 797-805

  • Phagocytes drive formation & resolution of neuroinflammatory lesions. The authors use in vivo imaging to track expression of proinflammatory & resolution enzymes & follow temporal changes in individual phagocytes polarization states in inflamed CNS.

    • Giuseppe Locatelli
    • Delphine Theodorou
    • Martin Kerschensteiner
    Research
    Nature Neuroscience
    Volume: 21, P: 1196-1208

  • Neutrophils rapidly respond to bacterial and fungal infections but can cause substantial collateral tissue damage if not restrained. Rosenbauer and colleagues show that the transcription factor PU.1 serves a cell-intrinsic role to prevent over-exuberant neutrophil responses to fungal infection.

    • Josephine Fischer
    • Carolin Walter
    • Frank Rosenbauer
    Research
    Nature Immunology
    Volume: 20, P: 546-558

  • Microglia have key roles in central nervous system (CNS) disease and homeostasis but their study can be challenging. Prinz and colleagues identify hexosaminidase subunit beta (Hexb) to be specifically expressed by microglia and stable even under inflammatory conditions.

    • Takahiro Masuda
    • Lukas Amann
    • Marco Prinz
    Research
    Nature Immunology
    Volume: 21, P: 802-815

  • Several specialized macrophage populations reside in the structures that border the mammalian CNS, including the meninges, perivascular spaces and choroid plexus. Prinz and colleagues review the development and characteristics of these ‘CNS-associated macrophages’ and describe their proposed contributions to CNS function and disease.

    • Katrin Kierdorf
    • Takahiro Masuda
    • Marco Prinz
    Reviews
    Nature Reviews Neuroscience
    Volume: 20, P: 547-562