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Showing 1–2 of 2 results
Advanced filters: Author: Marta Seczynska Clear advanced filters

  • The human silencing hub (HUSH) complex uses introns to distinguish intronless foreign DNA from intron-containing host DNA and modifies chromatin to silence transcription of retrotransposons and retroviruses.

    • Marta Seczynska
    • Stuart Bloor
    • Paul J. Lehner
    ResearchOpen Access
    Nature
    Volume: 601, P: 440-445

  • The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition over targets genome wide.

    • Christopher H. Douse
    • Iva A. Tchasovnikarova
    • Yorgo Modis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16