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Showing 1–3 of 3 results
Advanced filters: Author: Martin Göse Clear advanced filters

  • Using single-molecule and biochemical methods, Göse et al. demonstrated that the helicase-like ATPase of a Type III restriction enzyme establishes DNA sliding through a sequential series of nucleoprotein remodeling steps driven by DNA translocation.

    • Martin Göse
    • Emma E. Magill
    • Mark D. Szczelkun
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 689-698

  • MCM8-9 and HROB function together in DNA damage response. Here, the authors describe the mechanism of DNA unwinding by MCM8-9 and its activation by HROB. HROB makes direct contacts with both MCM8 and MCM9 and promotes DNA unwinding downstream of MCM8-9 loading and hexameric ring formation on DNA.

    • Ananya Acharya
    • Hélène Bret
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • An enzymatic ensemble including Dna2 functions in DNA end resection; the function of the single-stranded DNA binding protein RPA in this complex has been underappreciated. Here the authors employ molecular modeling, biochemistry, and single molecule biophysics to reveal RPA directly promotes Dna2 recruitment, nuclease and helicase activities.

    • Ananya Acharya
    • Kristina Kasaciunaite
    • Petr Cejka
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15