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Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype can be rescued by mutations in the retrotransposon coding sequence.

Juliane Glaser
Giulia Cova
Stefan Mundlos
ResearchOpen Access09 Jul 2025
Nature Genetics

Volume: 57, P: 1766-1776
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis

Stefan Knop
Monika Engelhardt
M. Svaldi
Research28 Aug 2019
Leukemia

Volume: 33, P: 2710-2719
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
Chemical-genomic dissection of the CTD code

RNA polymerase II is post-translationally modified on its C terminal domain and these modifications have been associated with different states of Pol II transcription. These modifications are now examined at a genome-wide level, and chemical inhibitors are used to argue that promoter-distal Ser7P is specifically placed anew by the Bur1 kinase.

Joshua R Tietjen
David W Zhang
Aseem Z Ansari
Research29 Aug 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1154-1161
Vigorous physical activity is important in maintaining a favourable health trajectory in active children: the CHAMPS Study-DK

Martin Sénéchal
Jeffrey J. Hebert
Niels Wedderkopp
ResearchOpen Access28 Sept 2021
Scientific Reports

Volume: 11, P: 1-8
Photoluminescence of planar and 3D InGaN/GaN LED structures excited with femtosecond laser pulses close to the damage threshold

Angelina Jaros
Jana Hartmann
Tobias Voss
ResearchOpen Access01 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters

Based on genome wide localization of initiating RNA polymerase II, general transcription factors and epigenetic marks in mouse thymocytes, transcription initiation platforms (TIPs) are evidenced, both at promoters and enhancers, as features able to promote tissue-specific expression.

Frederic Koch
Romain Fenouil
Jean-Christophe Andrau
Research17 Jul 2011
Nature Structural & Molecular Biology

Volume: 18, P: 956-963
Structural basis for activation of plasma-membrane Ca²⁺-ATPase by calmodulin

Julius Nitsche et al. demonstrate that binding of two calmodulin molecules displaces the regulatory domain of the plasma-membrane Ca²⁺-ATPase ACA8 to fully activate this Ca²⁺ pump by relieving the autoinhibition. This work provides structural evidence for the previously proposed bimodular activation mechanism.

Julius Nitsche
Inokentijs Josts
Henning Tidow
ResearchOpen Access26 Nov 2018
Communications Biology

Volume: 1, P: 1-10
An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia

D Martin
R Galisteo
J S Gutkind
Research15 Oct 2007
Oncogene

Volume: 27, P: 1844-1852
Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression

Corinna Hintermair
Kirsten Voß
Dirk Eick
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
Evaluating cognitive disturbances as treatment target and predictor of antidepressant action in major depressive disorder: A NeuroPharm study

Vibeke Høyrup Dam
Dea Siggaard Stenbæk
Vibe Gedsoe Frokjaer
ResearchOpen Access08 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-8

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