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Prevention of type 2 diabetes through prediabetes remission without weight loss

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

Arvid Sandforth
Elsa Vazquez Arreola
Reiner Jumpertz von Schwartzenberg
ResearchOpen Access29 Sept 2025
Nature Medicine

P: 1-11
Brain insulin sensitivity is linked to adiposity and body fat distribution

Brain insulin action regulates eating behavior and whole-body energy fluxes, however the impact of brain insulin resistance on long-term weight and body fat composition is unknown. Here, the authors show that high brain insulin sensitivity is linked to weight loss during lifestyle intervention and associates with a favorable body fat distribution.

Stephanie Kullmann
Vera Valenta
Martin Heni
ResearchOpen Access15 Apr 2020
Nature Communications

Volume: 11, P: 1-6
Impaired insulin action in the human brain: causes and metabolic consequences

In this Review, Martin Heni and colleagues outline the effects of insulin in the brain in humans and the relevance of the effects for physiology. The metabolic consequences of brain insulin resistance are discussed and possible future approaches to overcome brain insulin resistance and thereby prevent or treat obesity and type 2 diabetes mellitus are outlined.

Martin Heni
Stephanie Kullmann
Hans-Ulrich Häring
Reviews13 Oct 2015
Nature Reviews Endocrinology

Volume: 11, P: 701-711
Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

In young women, brain insulin action enhances peripheral insulin sensitivity, but only during the follicular phase of the menstrual cycle. This effect is absent in the luteal phase, possibly due to hypothalamic insulin resistance.

Julia Hummel
Charlotte Benkendorff
Martin Heni
ResearchOpen Access21 Sept 2023
Nature Metabolism

Volume: 5, P: 1475-1482
A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.

Stephanie Kullmann
Lore Wagner
Andreas L. Birkenfeld
ResearchOpen Access21 Feb 2025
Nature Metabolism

Volume: 7, P: 469-477
Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

Elko Randrianarisoa
Angela Lehn-Stefan
Martin Heni
ResearchOpen Access31 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Andreas Vosseler
Dongxing Zhao
Martin Heni
ResearchOpen Access24 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies

Róbert Wagner
Ádám G. Tabák
Martin Heni
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-7
Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

Clustering of patients with prediabetes using simple clinical features reveals six distinct groups with differing risk of developing type 2 diabetes and its associated complications.

Robert Wagner
Martin Heni
Andreas Fritsche
Research04 Jan 2021
Nature Medicine

Volume: 27, P: 49-57
Metabolic implications of pancreatic fat accumulation

There is growing evidence that fat accumulation in the pancreas can have consequences for metabolic health. This Review discusses the methods for detecting pancreatic fat and the potential causes and pathogenic consequences of pancreatic fat accumulation.

Robert Wagner
Sabine S. Eckstein
Martin Heni
Reviews20 Oct 2021
Nature Reviews Endocrinology

Volume: 18, P: 43-54
Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation

Julia Hummel
Louise Fritsche
Martin Heni
ResearchOpen Access17 Aug 2021
Scientific Reports

Volume: 11, P: 1-9
Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Theresa Ester-Nacke
Katharina Berti
Stephanie Kullmann
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-11
Dusp8 affects hippocampal size and behavior in mice and humans

Peter Baumann
Sonja C. Schriever
Paul T. Pfluger
ResearchOpen Access20 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

Stefan Z. Lutz
Mathias Falcenberg
Konstantinos Kantartzis
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-10
Acylated- and unacylated ghrelin during an oral glucose tolerance test in humans at risk for type 2 diabetes mellitus

Magnus Wolf
Martin Heni
Andreas Peter
ResearchOpen Access07 Jul 2023
International Journal of Obesity

Volume: 47, P: 825-832
Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Lore Wagner
Ralf Veit
Stephanie Kullmann
ResearchOpen Access17 Jun 2022
International Journal of Obesity

Volume: 46, P: 1662-1670
Health, pleasure, and fullness: changing mindset affects brain responses and portion size selection in adults with overweight and obesity

Ralf Veit
Lisa I. Horstman
Stephanie Kullmann
Research18 Jun 2019
International Journal of Obesity

Volume: 44, P: 428-437
Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Stephanie Kullmann
Martin Heni
Hubert Preissl
ResearchOpen Access09 May 2017
Scientific Reports

Volume: 7, P: 1-10
Dopamine Depletion Reduces Food-Related Reward Activity Independent of BMI

Sabine Frank
Ralf Veit
Hubert Preissl
Research09 Oct 2015
Neuropsychopharmacology

Volume: 41, P: 1551-1559

Search

Prevention of type 2 diabetes through prediabetes remission without weight loss

Brain insulin sensitivity is linked to adiposity and body fat distribution

Impaired insulin action in the human brain: causes and metabolic consequences

Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

A short-term, high-caloric diet has prolonged effects on brain insulin action in men

Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus

Slow deep breathing modulates cardiac vagal activity but does not affect peripheral glucose metabolism in healthy men

No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men

Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

Metabolic implications of pancreatic fat accumulation

Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Dusp8 affects hippocampal size and behavior in mice and humans

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans

Acylated- and unacylated ghrelin during an oral glucose tolerance test in humans at risk for type 2 diabetes mellitus

Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight

Health, pleasure, and fullness: changing mindset affects brain responses and portion size selection in adults with overweight and obesity

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Dopamine Depletion Reduces Food-Related Reward Activity Independent of BMI

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