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Showing 51–57 of 57 results
Advanced filters: Author: Martin Karplus Clear advanced filters

  • For the full potential of microbial genomics to be realized, a complete understanding of the metabolic capacities of microbial life is required. In this Innovation, the authors discuss new system-biology technologies that enable the identification of novel metabolites and their biochemical connections within metabolic networks.

    • Rainer Breitling
    • Dennis Vitkup
    • Michael P. Barrett
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 156-161

  • Protein-fragment complementation assays (PCAs) can be used to explore the dynamics of protein–protein interactions, and regulatory responses to intrinsic or extrinsic perturbations of biochemical pathways. Michnick and colleagues discuss the rationale behind the PCA design, and its manifold applications for drug discovery.

    • Stephen W. Michnick
    • Po Hien Ear
    • Eduard Stefan
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 569-582

  • Network analyses of protein–protein, genetic and drug–gene interactions have typically been limited to analyses at the whole-protein and whole-gene levels. This Review discusses how high-resolution network analyses at the domain and residue levels are providing valuable insights into diverse research fields that range from structural biology to human disease.

    • Colm J. Ryan
    • Peter Cimermančič
    • Nevan J. Krogan
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 865-879

  • The nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, the activity of which modulates many neurotransmitter systems. They are therefore therapeutic targets for the treatment of several central nervous system disorders. In this article, Taly and colleagues present recent advances in our understanding of the atomic structure, functional organization and conformational transitions of the nAChR that may be applied to drug discovery, and discuss agents currently in development.

    • Antoine Taly
    • Pierre-Jean Corringer
    • Jean-Pierre Changeux
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 733-750