EPH receptor (EPH)–ephrin signalling has crucial roles in embryonic development, as well as in adult tissue and organ maintenance, regeneration and pathogenesis. Here, Lackmann and colleagues discuss the potential and limitations of targeting EPH–ephrin function in the treatment of disorders including cancer, neurological diseases and inflammation, and assess therapeutic approaches that are currently under development.
- Andrew W. Boyd
- Perry F. Bartlett
- Martin Lackmann
