Nature Search

CRISPR germline engineering—the community speaks

Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.

Katrine S Bosley
Michael Botchan
Qi Zhou
Special Features12 May 2015
Nature Biotechnology

Volume: 33, P: 478-486
“Pink power”—the importance of coralline algal beds in the oceanic carbon cycle

High productivity and associated carbon uptake, significant carbonate deposits and substantial global area extension render coralline algal beds as highly relevant contributors to the present and future oceanic carbon cycle

Nadine Schubert
Fernando Tuya
João Silva
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Debate ethics of embryo models from stem cells

International discussion must guide research, urge Nicolas Rivron, Martin Pera and colleagues.

Nicolas Rivron
Martin Pera
Rosario Isasi
Comments & Opinion12 Dec 2018
Nature

Volume: 564, P: 183-185
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

Benjamin E. Reubinoff
Martin F. Pera
Ariff Bongso
Research01 Apr 2000
Nature Biotechnology

Volume: 18, P: 399-404
The proteomes of native and induced pluripotent stem cells

A comparison of embryonic stem cells and induced pluripotent stem cells on the proteome level reveals subtle distinctions between these cell types that might explain differences in their ability to differentiate into specific lineages.

Martin F Pera
News & Views29 Sept 2011
Nature Methods

Volume: 8, P: 807-808
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

Oluseun Adewumi
Behrouz Aflatoonian
Glyn N Stacey
Research17 Jun 2007
Nature Biotechnology

Volume: 25, P: 803-816
Stem-cell researchers must stay engaged

Recent developments have rekindled the ethical debate over human cloning. This is no time for complacency, caution Martin Pera and Alan Trounson.

Martin Pera
Alan Trounson
Comments & Opinion12 Jun 2013
Nature

Volume: 498, P: 159-161
Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours

Andrea AD Caricasole
Ron HN van Schaik
Adriana JM van den Eijnden-van Raaij
Research21 Jan 1998
Oncogene

Volume: 16, P: 95-103
Revisiting the Warnock rule

Is it time to reassess the 14-day rule for human embryo research?

J Benjamin Hurlbut
Insoo Hyun
Laurie Zoloth
Special Features09 Nov 2017
Nature Biotechnology

Volume: 35, P: 1029-1042
A step closer to making the mother of stem cells

In the earliest stages of mammalian development, individual cells possess the unrestricted potential to form a new organism. Researchers are closing in on the goal of growing these cells in the laboratory.

Martin F. Pera
News & Views17 May 2023
Nature

Volume: 617, P: 683-684
Stroke genetics informs drug discovery and risk prediction across ancestries

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Aniket Mishra
Rainer Malik
Stephanie Debette
ResearchOpen Access30 Sept 2022
Nature

Volume: 611, P: 115-123
Detection of an oxygen atmosphere on Jupiter's moon Europa

D. T. Hall
D. F. Strobel
H. A. Weaver
Research23 Feb 1995
Nature

Volume: 373, P: 677-679
Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV

Daniel J. Drucker
Qing Shi
Patricia L. Brubaker
Research01 Jul 1997
Nature Biotechnology

Volume: 15, P: 673-677
Erratum: Revisiting the Warnock rule

J Benjamin Hurlbut
Insoo Hyun
Laurie Zoloth
Amendments and Corrections08 Dec 2017
Nature Biotechnology

Volume: 35, P: 1211
In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells

In vitro production of human oocytes for the treatment of female infertility is a goal in reproductive medicine. Here, the authors establish in vitroconditions to generate human ovarian follicle-like cells from human embryonic stem cells.

Dajung Jung
Jie Xiong
Kehkooi Kee
ResearchOpen Access12 Jun 2017
Nature Communications

Volume: 8, P: 1-13
In vitro amniogenesis

Using a biomimetic culture platform to replicate the early biophysical environment of a developing embryo, human pluripotent stem cells can be directed towards amnion formation in vitro.

Martin Pera
News & Views29 Mar 2017
Nature Materials

Volume: 16, P: 394-395
The earliest Baltic amber in Western Europe

M. Murillo-Barroso
A. Martín Cólliga
M. Martinón-Torres
ResearchOpen Access31 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Multiancestry genome-wide association analyses identify new risk loci for stroke and stroke subtypes. Fine mapping and bioinformatics analyses of these risk loci point to mechanisms not previously implicated in stroke pathophysiology.

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Research12 Mar 2018
Nature Genetics

Volume: 50, P: 524-537
A new year and a new era

Manipulating cells from adult human tissue, scientists have generated cells with the same developmental potential as embryonic stem cells. The research opportunities these exciting observations offer are limitless.

Martin F. Pera
News & Views09 Jan 2008
Nature

Volume: 451, P: 135-136
Defining pluripotency

Retroviral marking of single human embryonic stem cells shows that cultures of these cells contain subpopulations with distinct functional properties.

Martin F Pera
News & Views28 Oct 2010
Nature Methods

Volume: 7, P: 885-887
Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have distinct cell cycle, metabolic, DNA methylation, and ATAC-seq profiles.

Kevin X. Lau
Elizabeth A. Mason
Martin F. Pera
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-18
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Stem cells exist in vitro in a spectrum of interconvertible pluripotent states. Here, authors show that pluripotency and self-renewal processes have a high level of regulatory complexity and suggest that genetic factors contribute to cell state transitions in human iPSC lines.

Timothy D. Arthur
Jennifer P. Nguyen
Kelly A. Frazer
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Low-risk reprogramming

New techniques circumvent a roadblock to the production of embryonicstem-cell-like lines from adult tissue. Such reprogrammed cell lines should be much safer to use for therapy.

Martin F. Pera
News & Views08 Apr 2009
Nature

Volume: 458, P: 715-716
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Cross-ancestry genome-wide association analyses in individuals of European and East Asian ancestry identify 11 new risk loci for intracranial aneurysms and highlight a polygenic architecture explaining a substantial fraction of disease heritability.

Mark K. Bakker
Rick A. A. van der Spek
Ynte M. Ruigrok
Research16 Nov 2020
Nature Genetics

Volume: 52, P: 1303-1313
The hESC line Envy expresses high levels of GFP in all differentiated progeny

Magdaline Costa
Mirella Dottori
Edouard G Stanley
Research23 Mar 2005
Nature Methods

Volume: 2, P: 259-260
The dark side of induced pluripotency

Induced pluripotent stem cells have great therapeutic potential. But genomic and epigenomic analyses of these cells generated using current technology reveal abnormalities that may affect their safe use. See Articles p.58, p.63 & p.68

Martin F. Pera
News & Views02 Mar 2011
Nature

Volume: 471, P: 46-47
Simpler and safer cell reprogramming

Induced pluripotent stem cells have been generated from mouse and human adult fibroblasts without the tumor-causing gene c-Myc.

Martin F Pera
Kouichi Hasegawa
News & Views01 Jan 2008
Nature Biotechnology

Volume: 26, P: 59-60
Improving the predictive power of mouse models

Comparative studies that integrate genetically diverse mouse models and in vitro cell-based assays will accelerate drug discovery for precision medicine.

Martin Pera
Andy Greene
Nadia A. Rosenthal
Comments & Opinion14 Aug 2024
Nature Biotechnology

Volume: 42, P: 1175-1177
Formation of human prostate tissue from embryonic stem cells

Renea A Taylor
Prue A Cowin
Gail P Risbridger
Research17 Feb 2006
Nature Methods

Volume: 3, P: 179-181
Stem cell culture, one step at a time

Introducing inhibitors of bone morphogenic proteins along with basic fibroblast growth factor (bFGF) into culture medium for human embryonic stem (ES) cells facilitates long-term maintenance of these cells in the pluripotent state, coming one step closer to the goal of a fully defined system for human ES cell (hESC) culture free of animal products.

Martin F Pera
News & Views01 Mar 2005
Nature Methods

Volume: 2, P: 164-165
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

Wnt/β-catenin signalling can regulate both self-renewal and differentiation of pluripotent stem cells. Here Kim et al.show that transcriptional regulation by nuclear β-catenin induces the differentiation of mouse epiblast stem cells and human embryonic stem cells, whereas cytoplasmic β-catenin supports their self-renewal.

Hoon Kim
Jun Wu
Qi-Long Ying
Research29 Aug 2013
Nature Communications

Volume: 4, P: 1-11
Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Mark K. Bakker
Rick A. A. van der Spek
Ynte M. Ruigrok
Amendments and Corrections22 Dec 2020
Nature Genetics

Volume: 53, P: 254
Epigenetics, vitamin supplements and cellular reprogramming

The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.

Martin F Pera
News & Views25 Nov 2013
Nature Genetics

Volume: 45, P: 1412-1413
Unnatural selection of cultured human ES cells?

Human embryonic stem (ES) cells maintained in culture can develop chromosomal abnormalities.

Martin F Pera
News & Views01 Jan 2004
Nature Biotechnology

Volume: 22, P: 42-43
Neural progenitors from human embryonic stem cells

Benjamin E. Reubinoff
Pavel Itsykson
Tamir Ben-Hur
Research01 Dec 2001
Nature Biotechnology

Volume: 19, P: 1134-1140
75 POSTNATAL METABOLIC ADAPTATION – THE EFFECTS OF GESTATION AND FEEDING

Jane M Hawdon
Martin P Ward Platt
Albert Aynsley-Green
Research01 Dec 1991
Pediatric Research

Volume: 30, P: 640
CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells

Daniella Herszfeld
Ernst Wolvetang
Martin F Pera
Research26 Feb 2006
Nature Biotechnology

Volume: 24, P: 351-357
Multi-ethnic genome-wide association study for atrial fibrillation

This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

Carolina Roselli
Mark D. Chaffin
Patrick T. Ellinor
Research11 Jun 2018
Nature Genetics

Volume: 50, P: 1225-1233
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra
Rainer Malik
Stephanie Debette
Amendments and CorrectionsOpen Access14 Nov 2022
Nature

Volume: 612, P: E7
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Hugh Markus, Peter Donnelly and colleagues report a genome-wide association study for ischemic stroke. They identify a SNP in HDAC9, a histone deacetylase gene, that is associated with large vessel ischemic stroke and suggest subtype-specific associations to ischemic stroke.

Céline Bellenguez
Steve Bevan
Hugh S Markus
Research05 Feb 2012
Nature Genetics

Volume: 44, P: 328-333
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Rainer Malik
Ganesh Chauhan
Martin Dichgans
Amendments and Corrections03 Jun 2019
Nature Genetics

Volume: 51, P: 1192-1193
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

The International Stem Cell Initiative tests methods in a multisite study to detect pluripotency and teratoma formation (PluriTest, Embryoid Body and Teratoma methods) in human pluripotent stem cells. Here, the authors provide guidelines for their application: only the teratoma assay offers evidence of malignant potential.

Thomas F. Allison
Peter W. Andrews
Shinya Yamanaka
ResearchOpen Access15 May 2018
Nature Communications

Volume: 9, P: 1-15
Extrinsic regulation of pluripotent stem cells

Martin F. Pera
Patrick P. L. Tam
Reviews09 Jun 2010
Nature

Volume: 465, P: 713-720
What if stem cells turn into embryos in a dish?

Martin F Pera
Guido de Wert
Patrick P Tam
Comments & Opinion29 Sept 2015
Nature Methods

Volume: 12, P: 917-919
A method for genetic modification of human embryonic stem cells using electroporation

Magdaline Costa
Mirella Dottori
Edouard G Stanley
Protocols05 Apr 2007
Nature Protocols

Volume: 2, P: 792-796
The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research

An international consortium is comparing the properties of 75 human embryonic stem cell lines.

Peter W Andrews
Nissim Benvenisty
Glyn N Stacey
Comments & Opinion01 Jul 2005
Nature Biotechnology

Volume: 23, P: 795-797
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed, producing retroviral-like particles.

Edward J. Grow
Ryan A. Flynn
Joanna Wysocka
Research20 Apr 2015
Nature

Volume: 522, P: 221-225
Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma

Alison M. Farley
David R. Braxton
Martin F. Pera
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
Why it is important to study human–monkey embryonic chimeras in a dish

The study of human–animal chimeras is fraught with technical and ethical challenges. In this Comment, we discuss the importance and future of human–monkey chimera research within the context of current scientific and regulatory obstacles.

Alejandro De Los Angeles
Alan Regenberg
Elias T. Zambidis
Comments & Opinion25 Jul 2022
Nature Methods

Volume: 19, P: 914-919
Lessons from human teratomas to guide development of safe stem cell therapies

Justine J Cunningham
Thomas M Ulbright
Leendert H J Looijenga
Reviews10 Sept 2012
Nature Biotechnology

Volume: 30, P: 849-857

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