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Showing 1–2 of 2 results
Advanced filters: Author: Martin R. Challand Clear advanced filters

  • Methylated RNA bases influence many life processes, but current detection methods lack the ability to detect individual methylations in single cells. Here, the authors use fluorescence hybridization probes sensitive to methylation to detect specific epitranscriptomic modifications at the single-cell level.

    • Rohan T. Ranasinghe
    • Martin R. Challand
    • David Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Mupirocin is a clinically important antibiotic, but the biosynthesis of its tetrahydropyran moiety—an oxygen heterocycle essential for its bioactivity—has remained elusive. Here, Willis, Crump and co-workers report an enzymatic reaction cascade catalysing this ring formation from a non-activated C–H bond.

    • Luoyi Wang
    • Alice Parnell
    • Christine L. Willis
    Research
    Nature Catalysis
    Volume: 1, P: 968-976