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Layered van der Waals compounds offer opportunities to visit new physical phenomena in two dimensional materials. Here the authors report large tunneling magnetoresistance through exfoliated CrI3 crystals and attribute its evolution to the multiple transitions to different magnetic states.

Photonic crystals can steer, shape, and sculpture the flow of photons. Here, the author fabricate a deep-subwavelength photonic crystal slab that supports ultra-confined phonon polaritons, by patterning a nanoscale hole array in h-BN.

Results of the phase 2 trial of CD19 CAR T cell therapy lisocabtagene maraleucel in patients with relapsed or refractory follicular lymphoma, most of whom were treated in a third-line or later setting, show encouraging objective response rates in these high-risk patients.

Shaping particle beams generated from laser-plasma accelerators is challenging. Here the authors demonstrate an all-optical method to structure the accelerated proton beam by modulating and imprinting the spatial laser profile onto the proton beam.

Few structural isomers of colloids, with identical masses but different structures, have been identified. Here, the authors observe an interesting example of structural isomerism in a pair of semiconductor magic-size clusters, which reversibly transform between one another with first-order unimolecular reaction kinetics.

This study seeks to tackle the question of why intermediate magmatic rock compositions are poorly represented on the Earth’s surface. The authors do so by tracking the evolution of the physical behaviour of immiscible Fe-rich liquids within a sample suite from the lava lake on the Kilauea Iki volcano, Hawaii.

Unlike natural supramolecular polymers, artificial counterparts do not have molecular recognition processes to preorganize the supramolecular complexes before final assembly. Here, the authors show supramolecular copolymerization driven by integrative self-sorting of two different monomers into discrete six-membered supramolecular complexes (rosettes).

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment composition independent of changes in clonal composition.

Scanning probe microscopy has been extensively applied to probe interfacial water but the probes tend to disturb the structure of water easily. Here, the authors report submolecular-resolution imaging of water clusters within the nearly non-invasive region by qPlus noncontact atomic force microscopy.

In correlated materials, a universal yet elusive feature is the occurrence of self-organized electronically ordered phases. Using equilibrium and pump–probe spectroscopy of a nickelate, the authors reveal ultrafast charge localization and vibrational coupling as precursors of a charge-stripe phase.

Transmission X-ray microscopy allows for the imaging of magnetic domains in thin film materials. Here, the authors exploit the angular dependence of the magnetic contrast to extract out-of-plane canting angles of stripe domains and topological defects in NdCo₅films buried under a NiFe layer.

The Mertz Glacier Polynya—a site of sea ice production and Antarctic Bottom Water formation—was strongly impacted following the calving of a massive iceberg in 2010. Here, the authors present a 250-year long sea ice reconstruction from the region and present evidence for a ~70-year calving cyclicity.

Heterogeneous composite materials, which are potentially useful for flexible electronics, are widespread in nature but synthetic examples are rare. Here, a site-specific hierarchical approach is used to fabricate composites with extreme local variations in elastic modulus and which are reversibly stretchable.

Genome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.

Electrons in graphene have a pseudospin, but controlling this degree of freedom is challenging. Evidence now suggests that the moiré superlattices arising in two-dimensional heterostructures can be used to electrically manipulate pseudospins.

Magnetic anti-skyrmions—chiral spin textures that could find applications in spintronics—have been recently observed in inverse tetragonal Heusler Mn_1.4Pt_0.9Pd_0.1Sn. Here, the authors observe anti-skyrmions in thin films of Mn_1.4Pt_0.9Pd_0.1Sn over a wide range of temperature and magnetic fields.

By controlling the density of phosphorus dopant atoms in single-crystal silicon it is possible to fabricate quantum dots that do not contain interfaces between different materials.

Hollow-core photonic-crystal fibres enable confinement of light on a much tighter scale than is possible with conventional fibre. But dispersion makes it difficult to transmit very short, sub 100 fs, pulses over long distances. A chirped structure could offer a solution.

Complex experimental protocols often require multi-modal data acquisition with precisely aligned timing, as well as behaviour-dependent interventions. Here, authors describe a software with an intuitive user interface for flexible data acquisition without dedicated synchronisation hardware.

Using complementary cryo-electron microscopy and functional studies, the authors demonstrate that botulinum neurotoxins exploit the accompanying nontoxic bacterial proteins, OrfXs and P47, activated by host digestive proteases, to greatly enhance their oral toxicity.

Measuring the mass of individual microbial cells remains challenging. Here, the authors present a cell balance to monitor the proliferation of single budding yeast cells under culture conditions in real time, showing that single cells increase total mass in multiple linear segments of constant growth rates.

The expanding mid-infrared (MIR) photonics market faces a significant challenge due to the lack of durable MIR optical fibers. Here, the authors fabricate gallate glasses with tantalum oxide, achieving enhanced water corrosion resistance and nonlinear refractive index, paving the way for robust long-length optical fibers, and advancing fiber-based MIR technologies.

Dry powder inhalers typically rely on carrier particles for drug delivery. Here, multi-focus 3D laser printing was used to fabricate microparticles with varied geometries, identifying a spiked Pharmacone design as the most effective for drug dispersion.

Hybrid MOF-glasses can be shaped and processed in analogy to conventional glasses. Here, microstructures are formed by thermal imprinting, whilst preserved porosity of the material enables its further use in responsive optics.

Wrinkling of cell nuclei is associated with disease. During development, the nucleus behaves like a sheet of paper and the wrinkling amplitude can be manipulated without changing its pattern.

Ni-catalysed chain-walking blossomed as an effective synthetic tool to functionalize C(sp³)–H bonds in hydrocarbon chains. This Review provides a detailed overview of the most recent advances in this field, focusing on site-selective and regioselective manipulations at previously out-of-reach C(sp³)–H sites.

Characterizing surfaces by Raman spectroscopy is limited by the competition of surface and bulk Raman responses. Here the authors use nanoporous plasmonic membranes to enhance surface Raman signals while suppressing bulk contributions.

Understanding the intricate relationship between alloying elements and oxidation processes is essential for the integrity and performance of materials. Here, the authors study the effects of atomic size and redox potential to understand the oxidation process and structural changes in surface oxides.

Continuous-flow biocatalysis with immobilized enzymes is a sustainable route for chemical synthesis, but inadequate biocatalytic efficiency caused by non-productive enzyme immobilization or enzyme-carrier mismatches presents a challenge for its application. Here, the authors report an approach for the fabrication of a high-performance enzymatic continuous-flow reactor via integrating scalable isoporous block copolymer membranes as carriers with an oriented one-step enzyme immobilization via a genetically fused material binding peptide.

A change in the style of rifting in the North Atlantic led to carbon fluxes from subcrustal melting that helped trigger the Palaeocene–Eocene Thermal Maximum, according to geochemical analyses of volcanic sequences as well as melting and tectonic modelling.

A surface-initiated solution growth method is used to synthesize single-crystal nanowires of organic–inorganic perovskite that show very low lasing threshold. Coating the nanowires with metallic films marginally affects the lasing performance.

In optomechanics, optical nonlinearities are usually regarded as detrimental and efforts are made to minimize their effects. Here, the authors study the complex dynamics, including chaos, arising from the coupling of such optical nonlinearities with the mechanical modes of a silicon nanobeam cavity.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Stress on land is dynamic, entailing swift and drastic changes. Integrated time-course stress and co-expression analysis predict a gene regulatory network that retraces a web of ancient signal convergences shared by land plants and their algal sisters.

A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.

The pressure that a fluid of self-propelled particles exerts on its container is shown to depend on microscopic interactions between fluid and container, suggesting that there is no equation of state for mechanical pressure in generic active systems.

The magnetic exchange interaction at buried interfaces between magnetic and non-magnetic materials can be probed by investigating the interaction of spin-polarized electrons with magnon modes in the ferromagnetic layer.