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Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.

Shahzada Khan
Irene Lew
Shomyseh Sanjabi
ResearchOpen Access25 Sept 2019
Nature Communications

Volume: 10, P: 1-11
Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro

Tomislav Sarenac
Martin Trapecar
Dusica Pahor
ResearchOpen Access30 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii

Jianbo Zhang
Yu-Ja Huang
Linda G. Griffith
ResearchOpen Access29 Mar 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-11
Coculture of primary human colon monolayer with human gut bacteria

The protocol describes coculture of a primary human colon monolayer derived from cells growing in colon organoids with aerotolerant bacteria, such as strains of B. thetaiotaomicron genetically engineered to respond to different stimuli in colonic microenviroments.

Jianbo Zhang
Victor Hernandez-Gordillo
Linda G. Griffith
Protocols28 Jun 2021
Nature Protocols

Volume: 16, P: 3874-3900
B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection

Martin Trapecar
Shahzada Khan
Shomyseh Sanjabi
Research19 Feb 2018
Mucosal Immunology

Volume: 11, P: 1158-1167

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Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro

An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii

Coculture of primary human colon monolayer with human gut bacteria

B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection

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Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract

Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro

An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii

Coculture of primary human colon monolayer with human gut bacteria

B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection

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Quick links