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Showing 1–6 of 6 results
Advanced filters: Author: Martin Vaeth Clear advanced filters

  • Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses.

    • Martin Vaeth
    • Jun Yang
    • Stefan Feske
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Metabolic processes may be different in immune cells between neonates and adults. Here the authors measure metabolic changes in human monocytes from different aged donors and find enhanced oxidative phosphorylation fueling myeloid differentiation in neonates which contrasts glycolytic responses in early childhood and more effective inflammatory response.

    • Greta Ehlers
    • Annika Marie Tödtmann
    • Dorothee Viemann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • BATF3 is a member of the AP-1 transcription factor family. Kastenmüller and colleagues show that BATF3 is needed to promote memory CD8+ T cell responses. Activated CD8+ T cells transiently upregulate BATF3, which in turn suppresses expression of proapoptotic BIM to promote cell survival.

    • Marco A. Ataide
    • Karl Komander
    • Wolfgang Kastenmüller
    Research
    Nature Immunology
    Volume: 21, P: 1397-1407

  • Regulatory T (Treg) cells are important for maintaining immune homeostasis. Here the authors show that STIM1 and STIM2, which activate the Ca2+ channel ORAI1, are essential for the differentiation of peripheral Treg cells into tissue-resident and follicular Treg cells and their ability to limit autoimmunity in mice.

    • Martin Vaeth
    • Yin-Hu Wang
    • Stefan Feske
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.

    • Stefan Klein-Hessling
    • Khalid Muhammad
    • Edgar Serfling
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15