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T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing cholangitis, an incurable autoimmune liver disease.

Hesham ElAbd
Mitchell Pesesky
Andre Franke
ResearchOpen Access11 Jun 2025
Nature Medicine

Volume: 31, P: 2306-2316
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Tom Karlsen and colleagues report a genome-wide association study for primary sclerosing cholangitis, a chronic bile duct disease. They identify susceptibility loci at MST1 and near BCL2L11.

Espen Melum
Andre Franke
Tom H Karlsen
Research12 Dec 2010
Nature Genetics

Volume: 43, P: 17-19
Orthotopic liver transplantation and what to do during follow-up: recommendations for the practitioner

In the past 15 years there has been continuous improvement in outcome after orthotopic liver transplantation (OLT). As such, the recognition and prevention of long-term post-OLT complications—rejection episodes, recurrence of underlying liver disease and the adverse effects of immunosuppression—have become ever more important. This Review suggests guidelines for the management of OLT recipients to improve long-term survival, overall outcome and health-related quality of life.

Daniel Benten
Katharina Staufer
Martina Sterneck
Reviews25 Nov 2008
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 6, P: 23-36
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Tom Karlsen and colleagues report an association study for primary sclerosing cholangitis (PSC), a severe liver disease, using the Immunochip array. They identify nine loci newly associated with PSC and examine pleiotropy with other autoimmune disorders.

Jimmy Z Liu
Johannes Roksund Hov
Tom H Karlsen
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 670-675
Muscle quality determined by computed tomography predicts short-term and long-term survival after liver transplantation

Isabel Molwitz
Franziska Recklies
Karoline Horvatits
ResearchOpen Access10 May 2023
Scientific Reports

Volume: 13, P: 1-13
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify four new susceptibility loci for PSC and quantify the correlation of common genetic variation shared between PSC and inflammatory bowel diseases.

Sun-Gou Ji
Brian D Juran
Carl A Anderson
Research19 Dec 2016
Nature Genetics

Volume: 49, P: 269-273

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T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Orthotopic liver transplantation and what to do during follow-up: recommendations for the practitioner

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

Muscle quality determined by computed tomography predicts short-term and long-term survival after liver transplantation

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

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