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Showing 1–7 of 7 results
Advanced filters: Author: Martina Turroja Clear advanced filters
  • In a cohort of 87 individuals with COVID-19, the memory B cell response at 6.2 months after the onset of disease evolves in a manner that is consistent with the persistence of SARS-CoV-2 antigen.

    • Christian Gaebler
    • Zijun Wang
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 591, P: 639-644
  • The Moderna (mRNA-1273) and Pfizer–BioNTech (BNT162b2) vaccines elicit anti-RBD antibodies similar to those elicited through natural infection with SARS-CoV-2, but their potent neutralizing activity was reduced or abolished by new viral variants of concern.

    • Zijun Wang
    • Fabian Schmidt
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 592, P: 616-622
  • Individual memory antibodies selected over time by natural infection with SARS-CoV-2 have greater potency and breadth than antibodies elicited by vaccination, whereas the overall neutralizing potency of plasma is greater following vaccination.

    • Alice Cho
    • Frauke Muecksch
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 600, P: 517-522
  • Pre-existing high-affinity antibodies alter germinal centre and memory B cell selection by lowering the activation threshold for B cells and through direct masking of their cognate epitopes, thereby permitting a diverse set of abundant lower-affinity clones targeting alternate epitopes to participate in the immune response.

    • Dennis Schaefer-Babajew
    • Zijun Wang
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 613, P: 735-742
  • A clinical study shows that immunotherapy with anti-HIV-1 antibodies maintains prolonged viral suppression after anti-retroviral treatment is discontinued and affects the size and composition of the intact but not the defective proviral reservoir.

    • Christian Gaebler
    • Lilian Nogueira
    • Michel C. Nussenzweig
    ResearchOpen Access
    Nature
    Volume: 606, P: 368-374