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Showing 1–3 of 3 results
Advanced filters: Author: Mary Clare Beytagh Clear advanced filters
  • EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

    • Mary Clare Beytagh
    • William A. Weiss
    News & Views
    Nature Cell Biology
    Volume: 24, P: 1189-1191
  • A druggable genome CRISPR-Cas9 screen followed by functional validation in preclinical lung cancer models uncovers Slc33a1 as a Keap1-mutant-specific targetable dependency.

    • Rodrigo Romero
    • Francisco J. Sánchez-Rivera
    • Tyler Jacks
    Research
    Nature Cancer
    Volume: 1, P: 589-602