Nature Search

Reproduction in Wild and Captive Dolphins

RICHARD J. HARRISON
R. C. BOICE
R. L. BROWNELL jun.
Research21 Jun 1969
Nature

Volume: 222, P: 1143-1147
Glycan recognition in globally dominant human rotaviruses

Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.

Liya Hu
Banumathi Sankaran
B. V. Venkataram Prasad
ResearchOpen Access06 Jul 2018
Nature Communications

Volume: 9, P: 1-12
Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection

Neonatal rotavirus infections are associated with gastrointestinal symptoms in some settings, but the role of host factors in clinical presentation is unclear. Here, Ramani et al. show that human milk oligosaccharides and microbiome are associated with symptomatic infection with neonatal strain G10P[11].

Sasirekha Ramani
Christopher J. Stewart
Mary K. Estes
ResearchOpen Access27 Nov 2018
Nature Communications

Volume: 9, P: 1-12
The pace of modern culture

Modern culture appears to change at a rapid rate compared with biological evolution. Lambert et al. test this and find that the pace of modern cultural evolution is surprisingly slow—slower than, for example, changes seen in Darwin’s finches.

Ben Lambert
Georgios Kontonatsios
Armand M. Leroi
Research20 Jan 2020
Nature Human Behaviour

Volume: 4, P: 352-360
A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity

GII.4 human noroviruses cause pandemic gastroenteritis and undergo epochal evolution. This study shows that a single Llama-derived nanobody neutralizes multiple GII.4 variants using a mechanism by targeting capsid plasticity.

Wilhelm Salmen
Liya Hu
B. V. Venkataram Prasad
ResearchOpen Access16 Oct 2023
Nature Communications

Volume: 14, P: 1-11
Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus

Rotaviruses cause life-threatening gastroenteritis in children and have been shown to have variations in glycan recognition from genetic alterations. Here, the authors use X-ray crystallography to indicate that these alterations can change the specificity of the virus from cows to infant humans.

Liya Hu
Sasirekha Ramani
B. V. Venkataram Prasad
ResearchOpen Access30 Sept 2015
Nature Communications

Volume: 6, P: 1-10
Telomere dysfunction activates YAP1 to drive tissue inflammation

How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thus revealing a link between telomere dysfunction and initiation of intestinal inflammation.

Deepavali Chakravarti
Baoli Hu
Ronald A. DePinho
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Gabriela Alvarado
Wilhelm Salmen
James E. Crowe Jr.
Amendments and CorrectionsOpen Access14 Oct 2021
Nature Communications

Volume: 12, P: 1
CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection

Culture methods for studying human norovirus infection have been recently established. Here, Ayyar and colleagues use human intestinal enteroids to dissect viral entry mechanisms and show that CLIC-mediated endocytosis and wound repair pathways are exploited by pandemic norovirus.

B. Vijayalakshmi Ayyar
Khalil Ettayebi
Mary K. Estes
ResearchOpen Access28 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity

GII.4 variants of human noroviruses cause pandemic viral gastroenteritis. The atomic structure of GII.4 virus-like particles reveal novel insights into capsid stability, dynamics and antigenic presentation potentially useful for ongoing vaccine development.

Liya Hu
Wilhelm Salmen
B. V. Venkataram Prasad
ResearchOpen Access10 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Noroviruses can cause gastroenteritis and there is currently no licensed vaccine or specific treatment available. Here, the authors isolate human monoclonal antibodies and characterize one antibody (NORO-320) with broad reactivity to genogroup I and II noroviruses.

Gabriela Alvarado
Wilhelm Salmen
James E. Crowe Jr.
ResearchOpen Access14 Jul 2021
Nature Communications

Volume: 12, P: 1-13
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

This crystallographic study shows the attachment of human rotavirus VP8* to histo blood group A antigen, and suggests how changes within the structure of VP8* could allow switching from sialylated to non-sialylated glycan receptor.

Liya Hu
Sue E. Crawford
B. V. Venkataram Prasad
Research15 Apr 2012
Nature

Volume: 485, P: 256-259
Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

The authors present a protocol for using the CRISPR–Cas9 genome editing system to knock out a gene of interest in human intestinal tissue–derived enteroids by lentiviral transduction and single-cell cloning.

Shih-Ching Lin
Kei Haga
Mary K. Estes
Protocols23 Feb 2022
Nature Protocols

Volume: 17, P: 1004-1027
Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment

Sravya V Bhamidipati
Anil Surathu
Harsha Doddapaneni
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Long-term organic carbon preservation enhanced by iron and manganese

Catalysis of simple organic carbon molecules into complex macromolecules by Fe and Mn may play a fundamental role in organic carbon preservation, to a degree that could substantially affect the Earth’s carbon and oxygen cycles.

Oliver W. Moore
Lisa Curti
Caroline L. Peacock
ResearchOpen Access02 Aug 2023
Nature

Volume: 621, P: 312-317
Norovirus replication, host interactions and vaccine advances

In this Review, the authors highlight recent advances in human norovirus biology, including classification, strain-specific differences in cell entry and innate immune responses. They also highlight progress in virus replication, neutralization assays, structural biology and antiviral targets, as well as the status and challenges of vaccine development.

B. V. Venkataram Prasad
Robert L. Atmar
Mary K. Estes
Reviews17 Jan 2025
Nature Reviews Microbiology

Volume: 23, P: 385-401
1198 ENDOGENOUS GLUCAGON FAILS TO INDUCE HEPATIC PHOSPHO ENOLPYRUVATE CARBOXYKINASE (PEPCK) IN NEWBORN GROWTH RETARDED RATS

Mary E Bussey
Edward S Ogata
Andrew Labarbera
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 310
Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

The development of indefinitely propagating human 'mini-guts' has led to a rapid advance in gastrointestinal research. This Review highlights the uses of enteroids, colonoids and organoids in functional transport physiology studies and host–pathogen studies.

Julie G. In
Jennifer Foulke-Abel
Mark Donowitz
Reviews28 Sept 2016
Nature Reviews Gastroenterology & Hepatology

Volume: 13, P: 633-642
Update on hypertrophic cardiomyopathy and a guide to the guidelines

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease. In this Review, Sen-Chowdhry et al. discuss the guideline recommendations for the evaluation and management of HCM, and provide a summary of the important advances in genetics, imaging, and molecular research on HCM.

Srijita Sen-Chowdhry
Daniel Jacoby
William J. McKenna
Reviews29 Sept 2016
Nature Reviews Cardiology

Volume: 13, P: 651-675
Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Lawrence Vernetti
Albert Gough
D. Lansing Taylor
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
Culture and differentiation of rabbit intestinal organoids and organoid-derived cell monolayers

Egi Kardia
Michael Frese
Robyn N. Hall
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-12
Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

Alexandra L. Chang-Graham
Jacob L. Perry
Joseph M. Hyser
ResearchOpen Access25 Jul 2019
Scientific Reports

Volume: 9, P: 1-20
Rotavirus infection

Rotaviruses are double-stranded RNA viruses that are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. This Primer gives an overview of the pathophysiology of rotavirus infection and describes how the introduction of vaccinations has altered the epidemiology and demographics of this disease.

Sue E. Crawford
Sasirekha Ramani
Mary K. Estes
Reviews09 Nov 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-16
Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response

Lynn Su
Wanzhi Huang
Timothy Palzkill
ResearchOpen Access06 Jun 2023
npj Vaccines

Volume: 8, P: 1-15
Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography

Group B rotaviruses have a unique fold in the glycan-binding domain specific for N- acetyllactosamine that potentially diverged from folds conserved in group A and C rotaviruses.

Liya Hu
Wilhelm Salmen
B. V. Venkataram Prasad
ResearchOpen Access05 May 2022
Communications Biology

Volume: 5, P: 1-8
Implementation of a fully remote randomized clinical trial with cardiac monitoring

Mayfield et al. describe the implementation and feasibility of an exclusively remote randomized clinical trial of hydroxychloroquine and azithromycin for the treatment of COVID-19. The trial included monitoring of cardiovascular safety which was successfully done using digital technologies.

Jacob J. Mayfield
Neal A. Chatterjee
Arun R. Sridhar
ResearchOpen Access20 Dec 2021
Communications Medicine

Volume: 1, P: 1-10

Search

Filter By:

Search

Quick links