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Showing 1–2 of 2 results
Advanced filters: Author: Mary Kaye Duff Clear advanced filters

  • Microglia clearance activity in adult brain is regulated epigenetically and region-specifically to match neuronal attrition rates. Uncoupling this activity from neural apoptosis leads to aberrant microglia activation & neurodegenerative-like changes.

    • Pinar Ayata
    • Ana Badimon
    • Anne Schaefer
    Research
    Nature Neuroscience
    Volume: 21, P: 1049-1060

  • Polycomb repressive complex 2 (PRC2) is a key mammalian epigenetic regulator that supports neuron specification during development. In this paper, the authors find that PRC2 plays a role in the survival of adult neurons. The loss of PRC2 activity in adult striatum led to the de-repression of multiple genes with bivalent histone methylation marks and to a fatal neurodegeneration phenotype.

    • Melanie von Schimmelmann
    • Philip A Feinberg
    • Anne Schaefer
    Research
    Nature Neuroscience
    Volume: 19, P: 1321-1330