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Showing 1–3 of 3 results
Advanced filters: Author: Mary-Jane Lombardo Clear advanced filters

  • An exploratory analysis of the phase 3 ECOSPOR III trial shows that a higher dosage of the oral microbiome therapeutic VOWST led to enhanced pharmacokinetics, increased species engraftment and altered microbiome and metabolite profiles, providing mechanistic insights into how it may prevent Clostridioides difficile infection recurrence.

    • Jessica A. Bryant
    • Marin Vulić
    • Matthew R. Henn
    ResearchOpen Access
    Nature Medicine
    Volume: 32, P: 186-196

  • DNA can be amplified and sequenced from a single cell, but unevenness of the sequence coverage complicates efforts to assemble a high-quality genome. Chitsaz et al. devise an algorithm to address this problem and apply it to assemble a genome draft of an uncultured single-cell marine organism from one lane of Illumina sequence data.

    • Hamidreza Chitsaz
    • Joyclyn L Yee-Greenbaum
    • Roger S Lasken
    Research
    Nature Biotechnology
    Volume: 29, P: 915-921