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Showing 1–7 of 7 results

Advanced filters: Author: Masahiro Onji Clear advanced filters

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

Toll-like receptor 9 detects microbial DNA, and is activated by cleavage in the endolysosome. Onji et al. discover that following cleavage, the two parts of the protein remain associated, and this interaction is required for DNA sensing.

Masahiro Onji
Atsuo Kanno
Kensuke Miyake
Research11 Jun 2013
Nature Communications

Volume: 4, P: 1-10
RANK drives structured intestinal epithelial expansion during pregnancy

The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation.

Masahiro Onji
Verena Sigl
Josef M. Penninger
ResearchOpen Access04 Dec 2024
Nature

Volume: 637, P: 156-166
Bat organoids reveal antiviral responses at epithelial surfaces

Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.

Max J. Kellner
Vanessa M. Monteil
Josef M. Penninger
ResearchOpen Access21 May 2025
Nature Immunology

Volume: 26, P: 934-946
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

TLR7 triggers immune responses upon sensing microbial RNA, and its endosomal localization is thought to prevent TLR7 activation by host RNA. Here, Kanno et al. show that TLR7 is also present on the surface of immune cells, and that anti-TLR7 antibody can prevent TLR7-mediated autoimmunity.

Atsuo Kanno
Natsuko Tanimura
Kensuke Miyake
Research04 Feb 2015
Nature Communications

Volume: 6, P: 1-12
DNase II-dependent DNA digestion is required for DNA sensing by TLR9

Discrimination between self and microbial DNA by innate receptors such as TLR9 relies on intracellular compartmentalization to increase specificity. Chan et al. show that activation of TLR9 by DNA ligands requires their processing by endolysosomal DNase II, restricting TLR9 activation to this organelle.

Mei Po Chan
Masahiro Onji
Kensuke Miyake
Research20 Jan 2015
Nature Communications

Volume: 6, P: 1-10
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Yuki Hitomi
Kazuko Ueno
Minoru Nakamura
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
AIF-regulated oxidative phosphorylation supports lung cancer development

Shuan Rao
Laura Mondragón
Josef M. Penninger
ResearchOpen Access27 May 2019
Cell Research

Volume: 29, P: 579-591