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Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model

Werner syndrome (WS) is a rare inherited disorder characterized by premature aging and atherosclerosis. Here, the authors mimic atherosclerosis with iPSC-derived macrophages and vascular cells and find that type I IFN signaling triggered by the reactivation of retrotransposable elements in WS macrophages induces vascular dysfunction.

Sudip Kumar Paul
Motohiko Oshima
Naoya Takayama
ResearchOpen Access10 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

The EWS-ATF1 fusion gene causes clear cell sarcoma (CCS). Here, the authors show that the downstream effects of EWS-ATF1 expression are strictly context dependent, and reveal the cell of origin for CCS to be Tppp3-expressing cells in peripheral nerves.

Shingo Komura
Kenji Ito
Yasuhiro Yamada
ResearchOpen Access05 Sept 2019
Nature Communications

Volume: 10, P: 1-19
Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells

Higher-order chromatin organization regulates the expression of transcriptional programs that control cell function. Here, the authors show that chromatin interaction profiles and nuclear positions at developmental gene loci differ between human somatic and pluripotent stem cells.

Hiroki Ikeda
Masamitsu Sone
Takuya Yamamoto
ResearchOpen Access20 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator

Masamitsu Sone
Nonoka Mitsuhashi
Yoshifumi Yamaguchi
ResearchOpen Access19 Sept 2024
Cell Death & Disease

Volume: 15, P: 1-12
Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

Joanna Y. Ip
Masamitsu Sone
Shinichi Nakagawa
ResearchOpen Access02 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

Daisuke Anegawa et al. investigated the mechanisms responsible for cold resistance in the Syrian hamster’s hepatocytes, which exhibited remarkable resistance to prolonged cold culture. Their results suggest that hepatocytes exhibit diet-dependent resistance to cold, which is linked to the retention of α-tocopherol in the liver.

Daisuke Anegawa
Yuki Sugiura
Yoshifumi Yamaguchi
ResearchOpen Access25 Jun 2021
Communications Biology

Volume: 4, P: 1-11

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Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model

Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas

Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells

Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator

Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

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