Seleno-insulins (SeIns) are known to exhibit different in vitro properties from wild-type insulin, upon replacement of one of the three disulfide bonds with diselenide bonds; however, the in vivo hypoglycemic effect remains poorly understood. Here, the authors optimize the synthesis of SeIns via native chain assembly and reveal in vitro resistance against the insulin-degrading enzyme, as well as the in vivo hypoglycemic effect in diabetic rats at a dose of 150 μg/300 g rat.
- Kenta Arai
- Masaki Okumura
- Michio Iwaoka
