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Cell–matrix interface regulates dormancy in human colon cancer stem cells

A genetic lineage-tracing system in human colorectal organoids identifies a population of dormant cancer cells that persists during chemotherapy and enables cancer regrowth, and the cell-adhesion molecule COL17A1 has a key role in the process of breaking dormancy.

Yuki Ohta
Masayuki Fujii
Toshiro Sato
Research07 Jul 2022
Nature

Volume: 608, P: 784-794
Marriage of black phosphorus and Cu²⁺ as effective photothermal agents for PET-guided combination cancer therapy

A balance between high stability and rapid degradation is required for effective photothermal anti-cancer agents. Here, the authors use Cu²⁺ to accelerate the degradation of black phosphorus nanosheets while enhancing its photothermal ability and apply this material for PET-guided, CDT-enhanced combination cancer therapy in mice.

Kuan Hu
Lin Xie
Ming-Rong Zhang
ResearchOpen Access08 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10

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Cell–matrix interface regulates dormancy in human colon cancer stem cells

Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Anemia in Patients with Severe Aortic Stenosis

Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

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Marriage of black phosphorus and Cu²⁺ as effective photothermal agents for PET-guided combination cancer therapy