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Showing 1–6 of 6 results

Advanced filters: Author: Masayuki Oginuma Clear advanced filters

Intracellular pH controls WNT downstream of glycolysis in amniote embryos

The authors show that metabolic activity leads to an increase in the intracellular pH of neuromesodermal precursors, and that this increase in pH, by allowing post-translational modification of β-catenin, is required for the activation of WNT signalling and mesodermal fate acquisition.

Masayuki Oginuma
Yukiko Harima
Olivier Pourquié
Research24 Jun 2020
Nature

Volume: 584, P: 98-101
Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB

Dorsal organizer initiates the dorsal-ventral axis formation in vertebrates. Here, the authors demonstrate that Tlr4/NFκB-mediated negative feedback regulation of Wnt/β-catenin signaling determines the precise size of the zebrafish dorsal organizer.

Juqi Zou
Satoshi Anai
Tohru Ishitani
ResearchOpen Access08 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging

Masayuki Oginuma
Moana Nishida
Tohru Ishitani
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Pathogenesis of CDK8-associated disorder: two patients with novel CDK8 variants and in vitro and in vivo functional analyses of the variants

Tomoko Uehara
Kota Abe
Tohru Ishitani
ResearchOpen Access16 Oct 2020
Scientific Reports

Volume: 10, P: 1-7
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy

A protocol for differentiating mouse and human pluripotent stem cells into muscle.

Jérome Chal
Masayuki Oginuma
Olivier Pourquié
Research01 Sept 2015
Nature Biotechnology

Volume: 33, P: 962-969
CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants

Yuri A. Zarate
Tomoko Uehara
Kenjiro Kosaki
Research25 Jan 2021
Genetics in Medicine

Volume: 23, P: 1050-1057