The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which enhances reparative neovascularization.
- Dipankar Ash
- Varadarajan Sudhahar
- Masuko Ushio-Fukai
