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Showing 1–6 of 6 results
Advanced filters: Author: Matej Durik Clear advanced filters

  • When senescent cells accumulate during adulthood they negatively influence lifespan and promote age-dependent changes in several organs; clearance of these cells delayed tumorigenesis in mice and attenuated age-related deterioration of several organs without overt side effects, suggesting that the therapeutic removal of senescent cells may be able to extend healthy lifespan.

    • Darren J. Baker
    • Bennett G. Childs
    • Jan M. van Deursen
    Research
    Nature
    Volume: 530, P: 184-189

  • Single-cell RNA-sequencing technology gives access to cell cycle dynamics without externally perturbing the cell. Here the authors present DeepCycle,a robust deep learning method to infer the cell cycle state in single cells from scRNA-seq data.

    • Andrea Riba
    • Attila Oravecz
    • Nacho Molina
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Muscle function decreases with age, and there are few preventative treatments. Zhang et al. find that different cell types in aging muscle express different senescence markers, giving insight into the complexity of senescence biology. They also show that aspects of muscle aging can be improved with senotherapeutic intervention.

    • Matej Durik
    • William M. Keyes
    News & Views
    Nature Aging
    Volume: 2, P: 570-572

  • Senescent cells, which accumulate with ageing, are also involved in organ development and disease. Here, the authors examine the beneficial and detrimental effects of chronic and acute senescent cells in kidney formation, repair, disease and ageing and how these can be therapeutically modulated.

    • Ines Sturmlechner
    • Matej Durik
    • Jan M. van Deursen
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 77-89

  • In this Review, Jan van Deursen and his colleagues discuss the recent progress in understanding the origin and identity of senescent cells in ageing and their contribution to age-related disease, in addition to discussing the potential for targeting these cells to counteract disease.

    • Bennett G Childs
    • Matej Durik
    • Jan M van Deursen
    Reviews
    Nature Medicine
    Volume: 21, P: 1424-1435