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Showing 1–4 of 4 results
Advanced filters: Author: Matej Horvath Clear advanced filters

  • Gelabert et al. examine genomic and archaeological data from Europe’s earliest farming communities in Central Europe (5500–5000 bce). They find differentiated genetic networks but no evidence of unequal access to resources linked to sex or kin.

    • Pere Gelabert
    • Penny Bickle
    • David Reich
    Research
    Nature Human Behaviour
    Volume: 9, P: 53-64

  • The study reveals the cryo-EM structure of human MICAL1, an enzyme that depolymerizes F-actin. Structural analyses show a conserved autoinhibition mechanism through intramolecular interactions between the N-terminal and C-terminal domains.

    • Matej Horvath
    • Adam Schrofel
    • Daniel Rozbesky
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • This computational protocol offers a framework to integrate high-dimensional -omics datasets. A three-pronged association study integrating intestinal microbiome and serum metabolome data with measures of human host physiology is used as an example.

    • Helle Krogh Pedersen
    • Sofia K. Forslund
    • Henrik Bjørn Nielsen
    Protocols
    Nature Protocols
    Volume: 13, P: 2781-2800

  • Horvath et al. structurally and biochemically characterize the full-length human DAPK2-14-3-3 complex to investigate the effects of binding to DAPK2 on its dimerization, activation by dephosphorylation of Ser318, and Ca2+/calmodulin binding. Their results provide mechanistic insights into 14- 3-3-mediated DAPK2 inhibition and highlight the potential of the DAPK2:14-3-3 complex as a target for anti-inflammatory therapies.

    • Matej Horvath
    • Olivia Petrvalska
    • Tomas Obsil
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14